Two parents homozygous for ApoE4 want to do base editing of sperm given AD risk to child. Here is the clinical trial: 1/1/2020: edit sperm, fertilize. 10/1/2020: edited baby born. 1/1/2090: we see if it worked. Not being a luddite, just pragmatic. technologyreview.com/s/612494/despi…

Thanks Sean. This figure beautifully illustrates the lack of precise editing of the CCR5 gene in the #crisprbabies.

This is looking ever more likely!

From technical missteps to ethical blunders, here's a list of 15 worrying things about the increasingly farcical CRISPR baby scandal. theatlantic.com/science/archiv…

'Genome editing' = precise modification of the genome by nuclease-assisted homology directed repair mechanisms. 'Genome bashing' = clobbering of the genome by error-prone non-homologous end joining at nuclease-induced double strand breaks. nature.com/articles/d4158…

Six years experience of genome editing in human iPS cells distilled down to these protocols. sciencedirect.com/science/articl…

Cold shock, HDR enhancer (IDT), and end-modified ssODN (IDT) greatly improves HDR efficiency in human iPS cells. sciencedirect.com/science/articl…

Induced pluripotent stem cell lines hold promise for improving studies of #Alzheimers disease. 🧠 The NIH has contracted with JAX's Bill Skarnes to generate a collection of engineered iPSC brain cell lines for the National Institute on Aging: jax.org/news-and-insig…

Synthego Launches Genome Engineering for iPS Cells genengnews.com/news/synthego-… via Genetic Engineering & Biotechnology News

'Mighty mice' splash down to Earth after stay on space station cnn.com/2020/01/07/wor…

ncov2019.live

washingtonpost.com/graphics/2020/…

Emily Mullin I am sorry you have to deal with this. Some such works are already published. As I told Jennifer, she and I have the first two covered, in order of appearance.

I'm very excited to present a truly special, free virtual scientific symposium that we've organized at Synthego on the applications of the #CRISPR technology. An all-star cast of speakers! Tuesday, October 20th. We call it "World CRISPR Day"! Register: worldcrisprday.com

BREAKING NEWS: The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”

#WorldCRISPRDay is in 7 days! More than 5,000 #genomeengineers have already registered. Have you? Lonza Aldevron Cardea (part of Paragraf®) Cell Microsystems The CRISPR Journal Wonder Collaborative 🦋 bit.ly/sclsky

Having trouble controlling the outcome of your editing experiments? Can't find an overlapping guide RNA? dCas9 may be the answer! Check out our new pre-print. biorxiv.org/content/10.110…

Read about a new effort between NIH, The Jackson Laboratory + CZI Science’s #NDChallengeNetwork grantees that could transform neurodegenerative research by: 👯‍♀️ Promoting reproducibility 🤝 Fostering collaboration 📊 Facilitating data sharing bit.ly/3JFbGnm