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This prompting technique is insanely useful. It basically acts like a LEVER that you can crank up and down. I discovered it a week ago and use it all the time now. [Short thread]

Our first paper is out in Cell! Led by Rohith Rajasekaran, we present a programmable reaction-diffusion system that generates synthetic protein waves, oscillations, and patterns for spatiotemporal circuit design and FM data-encoding in human cells. authors.elsevier.com/a/1iN8ZL7PXmeeN

A poorly designed barcode panel can negatively impact your single-cell multiplexing experiment. Demultiplexing sequencing data relies on the uniqueness of synthetic DNA barcodes and their distinguishably in sequencing reads. A poorly designed panel can result in ambiguity in

Exciting new work from our lab describing a novel platform for MHC-II recognition, called TRACeR, that uses just a single loop! Congratulation to Haotian Du, Jingjia Liu, and the team biorxiv.org/content/10.110…

Today I wish that all Women in Science get one less service committee, one less token invitation, one less request to do things without recognition but instead we get our papers cited, our work recognized and our views respected

Today starts a new era of genome engineering! We use RNA-only delivery to safely and efficiently deliver genes of interest to the human genome! Collins Lab UC Berkeley MCB A thread 🧵: nature.com/articles/s4158…

NEW content online! Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications dlvr.it/T5Fz27

Latest #BioRxiv on scRNA-seq reveals critical issues with droplet-based beads: Truncation compromises UMI identification, leading to inaccuracies in differential expression analysis. A must-read if your using 10X Genomics or dropseq in your research. tinyurl.com/mvapbxxw

Can AI rewrite our human genome? ⌨️🧬 Today, we announce the successful editing of DNA in human cells with gene editors fully designed with AI. Not only that, we've decided to freely release the molecules under the Profluent OpenCRISPR initiative. Lots to unpack👇

📌Preprint alert! Can naked extracellular RNA enter cells? Can it escape from endosomes into the cytosol? Can naked extracellular mRNAs be translated if not encapsulated in EVs or LNPs? Why do we have so many RNases in the blood? 🤔 A thread 🧵🪡 biorxiv.org/content/10.110…

So excited to finally share this project! We've discovered #seekRNA -a new #RNA that can be reprogrammed to take any cargo DNA and insert it into any target DNA sequence. This has big implications for gene editing and biotech. Read the fascinating story👇 biorxiv.org/content/10.110…

New preprint from our lab is now up on BioRxiv. This time it's a short but sweet one - a very useful method called POLAR-seq developed by @KlaudiaCiurkot in her 2 years in our group. We're keen to share this work early considering how useful it. biorxiv.org/content/10.110…

A new congressional blueprint for restructuring the NIH has been released. It proposes consolidating NIH's 27 IC's and centers into 15 categories, plus term limits for directors. It adds a national security review to grant apps. Public comments due Aug. 16 energycommerce.house.gov/posts/chair-ro…

🌟1/7 Check out our new pre-print “A cancer #immunotherapy modality based on dendritic cell #reprogramming in vivo”, where we reprogram #tumor cells in situ to efficiently present antigens as type 1 conventional dendritic cells (cDC1s). How effective is it?

Out today in Journal for ImmunoTherapy of Cancer is an exciting an eye-opening project led by Kristin DePeaux, PhD, former student in the lab! In it, we found a peculiar feature of oncolytic virus immunotherapy: viruses can infect some populations of immune cells! A brief 🧵 1/ bit.ly/4fNNNtn

One of the most important skills I teach my students&postdocs is how to communicate their research. Last week at NSF, I gave a keynote to (mostly) junior faculty on how to pitch their work. The talk resonated with many folks, so I'm sharing it publicly: mit.edu/~fadel/papers/…

🚨BREAKING. From a program officer at the National Science Foundation, a list of keywords that can cause a grant to be pulled. I will be sharing screenshots of these keywords along with a decision tree. Please share widely. This is a crisis for academic freedom & science.

I saw this paper, and several people sent it to me. Quite similar to what I've been doing for a while, so I wanted to give my review! Which is honestly mostly a review of what I've been up to in comparison to that paper, but should give you a nice perspective from someone close

Just a few months ago, the Baker and Garcia labs released con-concurrent preprints with incredible results. They designed de novo miniproteins that bound specific peptides presented in MHC-I. Now let me show how you can use BindCraft at Ariax Bio to do the same thing.

The peer-reviewed version of expansion in situ genome sequencing is now out in Science! The news is bittersweet – when we first revealed this last September, I never guessed it would be my final paper in academia, but a lot has changed. A few parting thoughts: