Gentili et al. performed genome-wide optical pooled CRISPR screens to identify genes regulating trafficking and signaling of the innate immune sensor STING. Broad Institute Matteo Gentili Blainey Lab cell.com/cell-systems/f…

Sun and Brown preview “Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening” Mount Sinai Genetics cell.com/cell-systems/f…

Will be in Hawaii for Winter QBio from 2/15-2/20, would love to learn cool new subjects from new friends. DM me if you are also around and want to chat(or surf together)!

This really remind me of the scene from "Your Name"

Excited and proud to have this paper published with Nature Communications today! Great project led by Juan L. Mendoza at UChicago Pritzker School of Molecular Engineering and HHMI. Excited for the future of the field - stay tuned for a full breakdown and walkthrough of our results! nature.com/articles/s4146…

Huge congrats to all the awardees, especially Dawn Chen Roman Barth Tong Zhang

New enzymes can unlock chemistry we never had access to before. Here, we introduce RFdiffusion2 (RFD2), a generative model that makes significant strides in de novo enzyme design. Preprint: biorxiv.org/content/10.110… Code: coming soon Animation credit: x.com/ichaydon (1/n)

So pleased to share that the Executive Committee of MIT has approved the promotion of Bryan Bryson to Associate Professor with Tenure.

Chatting with Bo about random interesting topics by the coffee machine is one of my greatest memories during the last year of grad school.

In January 2026, I will be joining Berkeley UC Berkeley as an Assistant Professor in the Department of Chemical and Biomolecular Engineering, College of Chemistry College of Chemistry, with exciting connections with world-class communities including the Lawrence Berkeley National

Thank you for the support, Shiyu!

And you can see Nathan's post for more details of the work.

I'm thrilled to share our work from Jonathan Weissman's Lab (sciencedirect.com/science/articl…). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two mechanistically distinct strategies for mitochondrially localized translation.

In vivo follow-up on MFSD12 and an embryonic lethal phenotype that we found was recoverable with cysteamine treatment. with David M. Sabatini and Fisher Lab Out today! pnas.org/doi/10.1073/pn…

The passing of David Baltimore is a huge loss to science and society. David was an inspirational leader and scientist, who touched the lives of all his mentees and motivated generations of scientists. He was compassionate, humble and deeply loyal to all his trainees. (1/2)

Excited to share the first paper from my lab in nature ! We repurposed the widely used research tool, proximity labeling, to demonstrate its therapeutic potential in antigen amplification for immunotherapy using mouse tumor models and patient samples. nature.com/articles/s4158…

Many of the most complex and useful functions in biology emerge at the scale of whole genomes. Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵

Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8) Preprint: biorxiv.org/content/10.110…