🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

It's a double feature on epigenetic memory today! Check another amazing new preprint on single-cell chromatin compaction and memory establishment from wizard postdoc Taihei Fujimori!

Finally, I would like to note that the NFZ TAD developed by Josh Tycko, Bintu Lab , and Bassik lab (link below) works very well in the synZiFTR toolkit, AND it can be further boosted with our new enhancement. That's all for now -- please stay tuned! 4/n biorxiv.org/content/10.110…

A little late, but we're excited to share our preprint in collaboration with the Greenleaf lab that uses single-molecule footprinting at an engineered locus in mammalian cells to understand how TF occupancy dictates expression!

We are hiring a lab manager/research assistant! More details and how to apply here: bintulab.com/2024/06/01/hir…

Our first RNA-centric preprint is online! Congratulations to Abby Thurm and the whole team - we're so excited to continue learning about effector domains in RBPs, and to hear your thoughts about what could come next!

Got out of the nucleus! Tested ~30,000 tiles from human RNA-binding proteins, found lots of domains that downregulate RNA&built an inducible synthetic RNA-binding protein for keeping target RNA at constant intermediate levels: biorxiv.org/content/10.110… So many follow-up projects!

(1/16) Check out our Simon Gaudin paper tiny.cc/icuazz from the Canzio lab out in Science Magazine today on how tuning local cohesin trajectories enables differential readout of the clustered Protocadherin (Pcdh) locus across different types of neurons.

🧬How do transcriptional cofactors recognize which genes to regulate?🧬 Check out our new preprint from Polly Fordyce Bintu Lab that tackles this question and provides the first-ever quantitative map of disordered transcriptional protein interactions (1/9) biorxiv.org/content/10.110…

Join us in Heidelberg for this great conference! Submit an abstract, we will select 20 talks (you have to register in the system first: embl.ungerboeck.com/PROD/emc00/Pub… )

Online Now: The H3.3K36M oncohistone disrupts the establishment of epigenetic memory through loss of DNA methylation dlvr.it/TF93Ry

I'm thrilled to announce that my PhD thesis work from Bintu Lab on how the H3.3K36M oncohistone disrupts the establishment of epigenetic memory is now out in the latest issue of Molecular Cell. shorturl.at/X9IZG (1/4)

Lastly, I would also like to give a shout out to Nate Hathaway’s lab UNC Pharmacy for writing a beautiful preview article elegantly describing our work. Please check it out here! : shorturl.at/hycOp (4/4)

Development of compact transcriptional effectors using high-throughput measurements in diverse contexts go.nature.com/3NMu00N

Incredibly excited that our paper linking single molecule states of TF binding to gene expression using quantitative thermodynamic models is out in Nature today. An amazing collaboration with the Bintu Lab. Congrats to Ben, Michaela, and Julia! nature.com/articles/s4158…

So we beat on. Gene/cell therapies often use proteins that could be recognized/rejected as non-self by our immune system. We combine algorithms to build proteins that are therapeutically relevant and can masquerade as our own parts doi.org/10.1101/2025.0…