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Congratulations to one of our new medicine laureates: Katalin Karikó (Katalin Kariko)! 🎉 An interview with her will be coming soon.

Early morning wake-up call! ⏰ Say good morning to one of the 2023 medicine laureates - Drew Weissman. We'll have an interview with our new #NobelPrize laureate coming out later today.

Nice story from Princeton on the BAF condensation Cell paper from the dream team of Ajinkya Patil Amy Strom Cigall Kadoch @PappulabWashU and colleagues!: engineering.princeton.edu/news/2023/10/0…

Congratulations to HHMI Investigator Bonnie L. Bassler, Jeffrey I. Gordon, & Dennis L. Kasper for being awarded the 2023 Albany Med Health System Prize! 🏆 Their collective work has advanced the field of human microbiome research & paved the way for new antibiotics. albanymed.org/news/2023-alba…

Negative DNA supercoiling induces genome-wide Cas9 off-target activity dlvr.it/Sx5d4z

Check out this study from Dr. Li-jia Qu's group at Peking University. It provides insights into intergeneric pre-zygotic hybridization barriers. Antagonistic RALF peptides control an intergeneric hybridization barrier on Brassicaceae stigmas: Cell cell.com/cell/fulltext/…

A study in Nature Immunology uses single cell profiling of T cells across the human lifespan to show that a suboptimal TCR shift in T cells as we enter older age results in a molecular signature that resembles that of T cells from newborns and children. go.nature.com/3PxeiHe

An intrinsically disordered region controlling condensation of a circadian clock component and rhythmic transcription in the liver dlvr.it/Sx8tq3

Congratulations and welcome to the 100 new members elected today to the National Academy of Medicine! #NAMmtg nam.edu/national-acade…

Congratulations to HHMI Investigators Darrell Irvine, Kristy Red-Horse (Kristy Red Horse), Phillip Zamore (ZamoreLabUMass), and Yi Zhang, and HHMI Professor Jennifer West, who have been elected as members of National Academy of Medicine! Learn more: hhmi.news/3Qb2g7K

Deeply humbled by this tremendous honor! I am incredibly grateful for the extraordinary opportunity of working at the Allen Institute alongside so many amazing colleagues.

In 21 papers across Science, Science Advances, and Science Translational Medicine, researchers with the #BICCN consortium present an atlas of the human and nonhuman primate brain in unprecedented detail. The results uncover the genetic organization of the human brain. scim.ag/4ro

70 Years of DNA Double Helix: Celebration of Breakthroughs in Life Science

This month's cover honors the issue’s special collection of commentaries by cancer researchers in China, commissioned through a collaboration with BioArt BioArt to showcase innovative research that aims to improve patient outcomes worldwide. bit.ly/4ecvf49

The collaboration with Cancer Discovery@CD_AACR has been very pleasant, and looking forward to more interesting collaborations in the future. Thanks Elizabeth McKenna

The 1st paper by Qu et al. shows lithocholic acid (LCA) alone can recapitulate the effects of calorie restriction (CR) in mice, including AMPK activation, muscle regeneration & increased grip strength and running capacity. LCA also increases health and lifespan in nematode worms

The 2nd paper demonstrates that LCA reproduces the benefits of CR via a TULP3–sirtuin–AMPK pathway that requires direct SIRT1 activation...

Later studies showed that resveratrol also activates AMPK, which prompted the development of more-potent, synthetic sirtuin-activating compounds (STACs)...

Excited to share our study nature, nature.com/articles/s4158… functionally defining a new memory CD8 subset, a novel CD8 T cell-driven complement activation pathway, and a new CD8 T cell-mediated pathogenic mechanism of allergy. huge kudos to Xin Liu IITU Tsinghua University