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Excited to share our latest cryo-EM work nature of Blundell group Cambridge Biochemistry BiocEM Cambridge on ligand regulation of DNA-PKcs, a key kinase in DNA damage response and repair. Inhibitor mode of action now better understood and more to explore! Check it out: nature.com/articles/s4158…

Happy to share our paper out in nature, which provides insights into activation and inhibition of a subset of extrasynaptic GABA(A) receptors. Paul Miller Dept. of Pharmacology, Univ. Cambridge BiocEM Cambridge and Smart Lab UCL Neuroscience nature.com/articles/s4158…

The Miller lab is delighted to announce its first publication! Mechanisms of inhibition and activation of extrasynaptic alpha-beta GABAA receptors. nature.com/articles/s4158…. nature Vikram Kasaragod Dept. of Pharmacology, Univ. Cambridge BiocEM Cambridge and Smart Lab UCL Neuroscience

The Miller lab Dept. of Pharmacology, Univ. Cambridge is looking for an enthusiastic postdoc to study antibody modulation of ion channels! A previous relevant publication from our group is nature.com/articles/s4158… Job details 👉 jobs.cam.ac.uk/job/35285 DEADLINE 15th JULY

New work from Manuel Carminati shows that dephosphorylation of RNA polymerase II by CPF (the 3' end processing machinery) promotes Pol II dimerisation. Cemre Manav @MRC_LMB European Research Council (ERC)

Midlands Cryo-EM Facility University of Leicester has a permanent post for an Experimental Officer to assist/ train users on everything Cryo-EM incl sample preparation, data collection &processing. We have a Titan Krios G3-Bioquantum-K3, screening microscope etc jobs.le.ac.uk/vacancies/5260…

Congratulations Amanda - keep up the stunning work!

Research Associate (Fixed Term) Cambridge University jobs.cam.ac.uk/job/41419/ Great job opportunity at Cambridge Biochemistry in the Pellegrini Lab . If you're interested in molecular mechanisms of DNA repair and replication, please apply and join us. We're looking forward to your application! 🙂

A year after she won the Lister Prize, we catch up with Amanda Chaplin to learn more about her work on DNA breakage and repair, and discover how the award will help her pursue her research goals 🔬 Read more here: lister-institute.org.uk/in-conversatio…

Yay, our new pre-print - many congrats to Zhan Yin Pellegrini Lab! 👏👏🥳 CryoEM insights into RNA primer synthesis by the human primosome biorxiv.org/content/10.110…

Team headed by Amanda Chaplin reports the cryo-EM structure of a DNA-PK trimer, which is a key enzyme for DNA double-strand break repair and they discuss the potential for higher order DNA-PK assemblies Amanda Chaplin BiocEM Cambridge University of Leicester cell.com/structure/full…