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Nawara et al. study how endothelial cells preserve clathrin-mediated endocytosis under fluid shear stress, highlighting how blood flow shapes cargo uptake and how the local vascular environment is a key regulator of CME dynamics. ow.ly/X88450W3px9

Special issue call for papers: Retinal Proteins: Experiment and Computation ow.ly/9rtJ50W4hPT

#OPENACCESS: Roles for PKC signaling in chromaffin cell exocytosis. Xiaohuan Chen, Nicole A. Bell, Breanna L. Coffman, David R. Giovannucci, and Arun Anantharam. ow.ly/fPJ950W3pHJ

Syntaxin1a is like a party guest: its moves depend on the crowd (clusters) and the vibes (cholesterol)! Fewer clusters or low cholesterol, and it’s free to roam. Weisgerber et al. maps its dance floor dynamics. ow.ly/Y6Tr50W3pO3

Butu et al. use highly coarse-grained molecular dynamics simulations to capture millisecond-timescale SNARE-driven membrane fusion, revealing how entropic forces from SNARE complexes drive membrane hemifusion and fusion. ow.ly/4SIT50W3pXr

#OPENACCESS: The authors characterize the two isoforms of SNAP-25, using circular dichroism and establish that intrinsically disordered proteins, SNAP-25A and -25B, make distinctly different structural changes upon varying the environmental conditions. ow.ly/KAae50W40xf

Special issue call for papers: Martin Karplus: In Memoriam ow.ly/FpIn50W4hrI

Synaptotagmin-1’s C2 domains are like Jenga towers: the AD3 spot is that one crucial block holding it all together! Pull it wrong, and the whole structure wobbles. Dominguez et al. shows how this tiny locus controls domain stability. ow.ly/Ga5P50W3qi8

#OPENACCESS: Rab3gap1 palmitoylation cycling modulates cardiomyocyte exocytosis and atrial natriuretic peptide release. Kobina Essandoh, Grace A. Eramo, Arasakumar Subramani, and Matthew J. Brody. ow.ly/U9xK50W3qr1

Fang and colleague use SCORE, a SNAP25-based FRET reporter, to track SNARE dynamics in real time, showing that FRET decay reflects SNARE complex disassembly, not diffusion. ow.ly/FY0B50W3qzf

#OPENACCESS: The authors find evidence to link the Rab3 GTPase cycle, via Gαq signaling, with the induction of cardiomyocyte secretory pathway and Atrial natriuretic peptide release, a peptide that helps reduce the cardiac workload. ow.ly/CpfK50W3qMw

Read about the cover art for the newly released issue of Biophysical Journal on the BPS Blog: biophysics.org/blog/second-ha…

In the New and Notable "Poking cells: AI can help here too," Juanyong Li and Kristen Billiar highlight the paper "Automated atomic force microscopy analysis using convolutional and recurrent neural networks." cell.com/biophysj/fullt…

Special issue call for papers: Modeling Biology at Multiple Scales: From Macromolecules to Cells, Dedicated to Jie Liang. ow.ly/u4ta50W4hzC

Special issue call for papers: Modeling Biology at Multiple Scales: From Macromolecules to Cells, Dedicated to Jie Liang. buff.ly/DqIVLt9

New study using a mechanical model to investigate how stress fiber and lamellipodia dynamics regulate collective cell migration reveals that strengthened stress fibers enhance cell rearrangements and stress alignment to promote coordinated movement. buff.ly/lnVjkRi

In the New and Notable "Cytoskeletal mechanics in collective cell migration ," Guang-Kui Xu highlights the paper "F-actin dynamics regulates collective cell migration by modulating cell shape and stress correlation." cell.com/biophysj/fullt…

Special issue call for papers: Martin Karplus: In Memoriam. ow.ly/MXu150W4hF9

A single-molecule study of DNA-supercoiling using optical tweezers in the presence of crowding molecules reveals the effect of co-solutes on the mechanical stress-driven base pair disruption in negatively supercoiled DNA. buff.ly/3Q35XnE

Special issue call for papers: Martin Karplus: In Memoriam. buff.ly/fQZ8LAV