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We are pumped to share with the community our new Nature Biotechnology paper on high-throughput RNA isoform sequencing with MAS-ISO-seq from a great collaboration across Broad Institute nature.com/articles/s4158…

Irvine Lab and Blainey Lab discovered that STING protein has previously unknown role as an ion channel, helping cells respond to danger signals such as viral infection.ow.ly/PuV150Psqgu Blainey Lab Science Magazine Koch Institute at MIT Broad Institute Ragon Institute

Our latest study, in collaboration with the Hacohen and Irvine labs, is out now in Science Magazine! It's a great story about a surprising finding regarding the mechanism of a human immune sensor science.org/doi/10.1126/sc…

And check out the fantastic MIT News piece by Anne Trafton about our STING paper news.mit.edu/2023/study-fin…

Excited to share our preprint on metabolic differences in the vaginal #microbiome. We find key differences in fatty acid metabolism among #Lactobacillus species & leverage those findings to identify a potential new therapy for bacterial vaginosis (BV) & #WomensHealth 🧵 (1/n)

We are excited to share our new bioRxiv about CROPseq-multi with the community, many thanks to our Russell Walton for this Tweetorial about his work with Yue Qin! Broad Institute MIT Dept of BE Eric and Wendy Schmidt Center

New bioRxiv! w/ our high-throughput screening approach, screened 1.3M+ antibiotic combos against high priority, drug-resistant bacterial pathogens, identified small molecule P2-56 as a potentiator of rifampin against A. baumannii and K. pneumoniae biorxiv.org/content/10.110…

Now out on bioRxiv! Thank you to our alum Becca J. Carlson for this great Tweetorial! Broad Institute

We're hiring! We are seeking an exceptional postdoc associate to help us work on solving the antibiotic resistance crisis, details and apply here: broadinstitute.avature.net/en_US/careers/…

We're hiring for a postdoc to work with us on the technical development and deployment of optical pooled screening (OPS) technology! Details and apply here: broadinstitute.avature.net/en_US/careers/…

Out now in @cellcellpress - our story about metabolic differences in the vaginal microbiome led by Meilin Zhu Broad Institute in collaboration with the Doug Kwon at Ragon Institute and others: cell.com/cell/fulltext/…

Available now via bioRxiv is our preprint on live-cell transcriptomics with engineered virus-like particles Broad Institute biorxiv.org/content/10.110…

In collaboration with Reuben Saunders, Jonathan Weissman's Lab, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue. Check it out! biorxiv.org/content/10.110…

In collaboration with William Allen and Xiaowei Zhuang, we have developed Perturb-multi: biorxiv.org/content/10.110…

Excited to see the work from Matteo Gentili Becca J. Carlson and others from our collab with the Hacohen lab Broad Institute out now!

Excited to share the 1st of several stories dissecting TEs + chromatin in normal/malignant hematopoiesis. We identified histone demethylases KDM4A/C as vulnerabilities in DLBCL + discovered novel KDM4 inhibitors. Preprint👇 Broad Institute Boston Children's biorxiv.org/content/10.110…

Recently published in PNASNews our high-throughput screen of 1.3M+ antibiotic combos identified P2-56 as a rifampin potentiator against A. baumannii & K. pneumoniae. pnas.org/doi/10.1073/pn…

Researchers at the Broad Institute have created a pipeline for discovering unique combinations of molecules that increase the effectiveness of #antibiotics against drug-resistant bacteria. ✏️ Abstract: bit.ly/4kry8lu 📰 Press Release: bit.ly/3T5TSap

Excited to share my primary PhD work! Vibrio isolates can produce peptide deformylase inhibitors that induce prophages in their lysogenic competitors. Not only is it SOS-independent, but also serves as the first example linking translational stress with prophage induction 👀 1/

Out now in Cell Reports our collab w/ Biederer Lab on image-based pooled genetic screening to identify regulators of synapse formation cell.com/cell-reports/f…