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LR-ExM using tri-functional anchors enhances #expansionmicroscopy labeling efficiency to resolve molecular-scale features in cells. Work by Xiaoyu Shi in collaboration with Ian Seiple lab. biorxiv.org/cgi/content/sh…

Cytoplasmic protein granules organize kinase-mediated RAS signaling in cancer - our collaboration with Trever Bivona lab: biorxiv.org/content/10.110…

The bright gets brighter: Split red fluorescent proteins for the visualization of endogenous proteins and synapses disq.us/t/3ibmj76

@jeff_hussmann It takes a village: great collaboration between Chan Zuckerberg Biohub Network Jonathan Weissman's Lab Bo Huang Lab Barbara Panning Gan Lab - thanks to all.

Still more to be done, but here is the 3rd-gen of green-colored split fluorescent protein for protein tagging and signal amplification biorxiv.org/cgi/content/sh…

Here is a truly versatile and modular system for split enzymes, as demonstrated for split HaloTag: disq.us/t/3t8m5zq

Transfer learning solves the challenge of training data collection for supervised learning and also improves the performance of self-supervised learning. For image denoising, see bioRxiv dx.doi.org/10.1101/2021.0… and GitHub github.com/BoHuangLab/Tra…

Endogenous tagging + 3D live-cell imaging + mass-spec interactome = opencell.czbiohub.org, an open-source map of the human proteome. So excited for our first release, wonderful collaboration with Matthias Mann Lab Loïc A. Royer 💻🔬⚗️ & many other colleagues. OpenCellCZB

Just coming out in Cell: authors.elsevier.com/sd/article/S00…. Our incredible collaboration with the Bivona Lab and Tulpule Lab shows how cytoplasmic protein granules formed by a variety of oncogenic kinase fusion mutants can activate RAS/MAPK signaling.

Tagging and purification of endogenous proteins for single particle cryo-EM. Nice collaboration with Yifan Cheng ! biorxiv.org/content/10.110…

Expansion microscopy gets help fron new anchors

Thanks to Reiter Lab's cool work. LR-ExM is already helping discoveries in centrosome/ciliary structures.

LR-ExM and eSPIM also helped resolving endosome structures and dynamics in zebrafish embryo.

LR-ExSIM and LR-ExSTORM reveal subcellular protein organization. Xiaoyu Shi, Qi Li and colleagues report the development of label-retention expansion microscopy (LR-ExM): bit.ly/3qR6vXX Ian Seiple Bo Huang Lab @jiapeichen @dhivkmr Reiter Lab ExM #Technology

The OpenCell is now open! doi.org/10.1126/scienc…

Here is our first step towards predicting cellular activities of proteins from their amino-acid sequences using deep-learning: biorxiv.org/content/10.110…

Endogenous tagging for structural biology pnas.org/doi/10.1073/pn…

HybriSeq: our venture into single-cell RNA profiling by combing in situ hybridization and single-cell sequencing. doi.org/10.1101/2023.0…