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We found high fat diet-induced blood pressure elevation is in part via endothelial lipid droplets suppressing eNOS! Thank you all coauthors and collaborators who helped with this long project:) In press in Journal of Clinical Investigation

How #Obesity➡️#Hypertension? Excess #LipidDroplet⏬eNOS in macro-/microvascular #EndothelialCells, via 1⃣⏬eNOS mRNA stability 2⃣⏫MCP1 autocrine EC Atgl KO🐭-> Hypertension ~10 mmHg SBP ⏫Atherosclerosis (AAV8-PCSK9) The Arany lab Journal of Clinical Investigation 2023 www-jci-org.proxy1.lib.uwo.ca/articles/view/…

Really cool UNC McAllister Heart seminar today by Dr. Murfee Lee Murfee on the microvascular network in cultured tissue!

#Mechanobiology #SmoothMuscleCell #Piezo1 & Pressure (hypertensive 180/120 mmHg) ▶️cPLA2-mediated #LipidDroplet formation & #FoamCell phenotype in SMC in 2 h🤠 SMC Epigenetics by 8 h Yoda1 (Piezo1 activator): LAD-heterochromatin, H3K9me3 Cut&Tag Piezo1 enriched at SMC nuclear

Our paper is now online! Here we investigate the direct effect of lipolysis on AMPK signaling in adipocytes. Using our real-time FRET sensor we show lipolysis genereates long-chain acyl-CoAs that are involved in allosteric activation of AMPK.#lipidtime rdcu.be/duWEg

High fat consumption & blood pressure elevation ft. Boa Kim, Wencao Zhao, Soon Tang, Michael Levin, @_AyonIbrahim, Yifan Yang, Ling Lai, Jian Li, The FitzGerald Lab, The Arany lab (PennCVI/ Penn IDOM) Emilia Roberts & Richard Assoian (PennSysPharmATT) tinyurl.com/35b3tfm5

Beautiful parallel work on endothelial LDs by Nabil in Bill Sessa's lab!👏

The FASEB Science Research Conference (SRC) on Vasoregulation: Signaling and Multicellular Inputs will take place from August 4 to August 8, 2024, in Tucson, AZ. Register now at web.cvent.com/event/efa86d30… #VASOSRC

Age-related loss of Notch3 underlies brain vascular contractility deficiencies, glymphatic dysfunction, and neurodegeneration in mice: buff.ly/3SpHVg4 Northwestern Feinberg School of Medicine #Neuroscience #VascularBiology

100th Anniversary #Viewpoint by Joseph Loscalzo Brigham and Women's Hospital: Nitric oxide in vascular biology: elegance in complexity: buff.ly/3OMTyeZ

Commentary: Lipid droplets in the endothelium: The missing link between metabolic syndrome and cardiovascular disease? buff.ly/3UPznkm MCRI Jaffe Lab Tufts Medical Center Cedars-Sinai Related article: buff.ly/49HMXe0

Online Now: Endothelial lipid droplets drive atherosclerosis and arterial hypertension dlvr.it/T3Yz9c #trends #endocrinology #metabolism

Online now! Futile lipid cycling: from biochemistry to physiology dlvr.it/T3ndPn

Sharing a preprint: Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK biorxiv.org/content/10.110… Thanks to Caitlyn Bowman and The Arany lab for a great collaboration.

🛡️ Protecting endothelial dysfunction! Researchers characterized the function of lipid droplets 💧 and adipose triglyceride lipase-induced #lipolysis in the regulation of #endothelial function. 👉 bit.ly/3wWvMar

#NAVBO Member Publication Alert Endothelial lipid droplets suppress eNOS to link high fat consumption to blood pressure elevation Zoltan Arany group Journal of Clinical Investigation 2023 Boa Kim Wencao Zhao The FitzGerald Lab The Arany lab jci.org/articles/view/…

Beyond excited to share my first paper from my PhD Daniel Fazakerley Lab Inst Metabolic Science-Metabolic Research Labs now out in The EMBO Journal! Special thanks to Sam from TVPLab and Dougall Norris for co-leading this project with me. We found that many cell culture models, despite living in 18% oxygen, are hypoxic! 🧵below:

#NAVBO Member Publication Alert Shear stress control of vascular leaks and atheromas through Tie2 activation by VE-PTP sequestration Donald McDonald & Dietmar Vestweber groups EMBO Mol. Medicine 2023 embopress.org/doi/full/10.15…