Alerting all potential new PhD students interested in protein folding, misfolding and membrane proteins. We have FIVE projects available spanning biophysics to nanotechnology! Apply via FindAPhD. We have a super exciting and supportive lab The Astbury Centre

“Anti-microbial resistance could kill us before the climate crisis does”. Leaders across the globe need to take this threat seriously. It's going to require action from everyone. #AMR #Superbugs newstatesman.com/encounter/2022…

DALL-E’s amazing images are popping up all over the web. That software uses something called a diffusion model, which is trained to remove noise from static until a clear picture is formed. Turns out diffusion models can design proteins too!

Check out our latest preprint with yiying yang Robin Corey @robincorey.bsky.social @JulienMarcoux2 Phill Stansfeld. YifL/LptM promotes oxidative maturation of the lipopolysaccharide translocon by substrate binding mimicry. biorxiv.org/content/10.110…

Anyone for PIMs? Modelling mycobacterial membranes to tackle TB: pnas.org/doi/10.1073/pn…. Chelsea Brown's first 1st author paper of her PhD, with Robin Corey @robincorey.bsky.social, @DrLizF, CHARMM-GUI, and excellently co-coordinated by matthieu Chavent.

Looking at an old problem with new eyes: can Alpha-fold models help identify functionally important residues? Just out @WileyPolymers onlinelibrary.wiley.com/doi/10.1002/bi…

Wow, #AlphaFold 2.3 is producing great results on protein complexes that did not work in 2.1 or 2.2. Previously we would get proteins or peptides not bound at all, or poor iPTM scores & inconsistent results from models 1-5. Now on several systems we get results that make sense.

In nature today (open access), we report the structural and mechanistic basis of how bacteria harvest energy from air. We reveal a novel enzyme, Huc, consumes atmospheric levels of hydrogen gas and transfers the derived electrons for aerobic respiration. nature.com/articles/s4158…

In our just accepted paper in Angewandte Chemie with RadfordLab & Neil Ranson in The Astbury Centre we used In-Cell PELDOR/DEER complemented by CryoEM to show the BAM complex adopts a lateral closed conformation in E coli cells in presence of antibiotic darobactin-B: onlinelibrary.wiley.com/doi/10.1002/an…

Excited to see @milkowilko's structure of human arctic Aβ1-42 ex vivo from AppNL-G-F mouse brain. Check out the paper in Nature Communications rdcu.be/dcnfb to see tomograms showing fibrils in unfixed brain tissue from Conny Leistner and @drrenefrank The Astbury Centre @astbury_BSL

Finally, we can share fantastic structures of 'utilisomes' - glycan processing machines from the OM of our gut microbiota. Out today in nature rdcu.be/dd0dy Joshua White Augustinas Silale Dave Bolam & van den Berg. The Astbury Centre @Astbury_BSL @ScienceLeeds University of Newcastle

Another blow to the Central Dogma? Same DNA sequence can originate very different proteins if the RNA is later recoded. This is unlike splicing, quite awesome. I doubt that only octopuses & similar make it, looks like a cool trick for transient adaptation cell.com/cell/fulltext/…

It's so great to see our RFdiffusion paper now live nature. This article from Ewen Callaway gives a great overview of RFdiffusion and protein diffusion models more broadly, and also highlights some of the ways people are already using it in their own research!

Some NMR animations to help teaching this semester: karamanoslab.com/nmr-animations. Good excuse to play with JavaScript #NMRchat

Are you interested in chaperones? Do you have expertise in biophysics or protein structure analysis (e.g. by MS, NMR, FRET)? We have a Biotechnology and Biological Sciences Research funded 3 yr postdoc position available, which is an exciting collaboration with RadfordLab and Zhuravleva Lab BioNMR@Leeds (1/3)

Just in time for Christmas! Excited to see our fibril structures published, showing changing polymorphism of IAPP during the course of amyloid assembly. As always, brilliant team effort from the amyloid team, thanks all The Astbury Centre Neil Ranson RadfordLab sciencedirect.com/science/articl…

Happy to finally share our work demonstrating the de novo design of b-barrel nanopores with complete control of the pore size and shape. Fantastic collaboration between my group VIB_StructuralBiologyBrussels, Institute for Protein Design, RadfordLab and Hiller Lab! biorxiv.org/content/10.110…

.Bob Schiffrin and I have written a preview for Molecular Cell on David Balchin's study of chaperone coordination during co-translational protein folding. Check out our preview: authors.elsevier.com/a/1jPbE3vVUPRm…, and the exciting paper: sciencedirect.com/science/articl…

New paper from our team using smFRET MS and cryoEM to see SurA delivering OMPs to BAM. Well done all - proud to work with you all! rdcu.be/dSDfs.

Very excited to share our paper on outer membrane assembly which includes the first cryoEM structures of BAM-SurA complexes. A great team effort with Jim Horne Joel Crossley Anton Calabrese RadfordLab Neil Ranson nature.com/articles/s4146…