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When I just started at the IMP I had a short side discussion with @PauliGroup about one of her ideas and we decided to join forces. Truly collaborative we went on an adventure driven by FriedaLeesch and Laura Lorenzo-Orts, published today rdcu.be/c3Ia3 nature.

Thanks for reaching out. Here is how you can help AFAD - Disaster and Emergency Management provides direct rescue, support in disaster zones lnkd.in/e92YBAXY AHBAP - Anatolia People and Peace Platform, a nonprofit, with collaborative work with AFAD ahbap.org/disasters-turk…

Congrats to team lead by Cathy Spangler and Aleksandra Skrajna on their tour de force in chromatin structural biology published today in Nature Chemical Biology. Really proud to add that the first 9 authors on this paper are women! nature.com/articles/s4158…

Spotlight on grad student Amelia McCue (Kuhlman lab) If you hang around the bio-focused students at UNC long enough, you will hear words like “protein” / “small-molecule” thrown around in conversation. They are a big deal for biochemists & biophysicists,,, go.unc.edu/Ws3k9

Can titin missense mutations trigger cardiac disease? Can we inform pathogenicity of missense variants? Check our latest preprint "Amino acid substitutions hydrophilizing the core of titin domains cause dilated cardiomyopathy"! biorxiv.org/content/10.110…

Exited to share my thesis project! Huge thanks to co-mentors Nick Brown at UNC Pharmacology and Haselbach lab. Also couldn’t have made it happen without major input and contributions from Ellen Zhong (cryodrgn❄️🐉) Hahn Lab (microscopy) Wei Zhang (ubiquitin variants) and others 🙏

Presenting! My first first-author preprint as a research-track faculty. Mucopolysaccharidoses (MPS) are a group of rare lysosomal storage disorders that occur because of dysfunction, often inherited, of enzymes in glycosaminoglycan degradation pathway. biorxiv.org/content/10.110…

Our semester ended on a high note with the publication of the lab's first review article! Our article "Multivalency emerges as a common feature of intrinsically disordered protein interactions" is now published in Current Opinion/Research in Structural Biology. Congrats to Emily and Garrett! bit.ly/3NzeDJ8

Check out our preprint on the Doa10 E3 ligase, the key player in ERAD-C. We combined cryo-EM, MD simulations (another cool collaboration with JC Gumbart and Diane Lynch!), and biochemical approaches to reveal how Doa10 recognizes its substrate proteins. biorxiv.org/cgi/content/sh…

Check out our latest paper in Science Advances! We reveal nucleotide-induced changes in PINK1 using cryo-EM, and investigated PINK1's interaction with reported PINK1 activating molecules KTP/kinetin. Grateful to @komander_lab WEHI (Walter and Eliza Hall Institute) and other. science.org/doi/10.1126/sc…

Duplicated Selection To Exclude Rubbish particles (DuSTER) is a method for facilitating the structural analysis of small biomolecules. DuSTER uses the reproducibility of the particle centering during 2D classification to exclude the low S/N. biorxiv.org/content/10.110…

Excited to share my final PostDoc work! Introducing MagIC-cryo-EM🪄 & DuSTER🧹, these methods reduce cryo-EM sample requirements (0.0005 mg/mL), enabling ALL biologists to explore the structural basis of diverse biological events! BioRxiv: biorxiv.org/content/10.110…

Fixing this post, as requested :-) Dr. Chrystal Ama Starbird PDB Depositer, zara weinberg 🧪🧙🏻‍♀️ and @mary_munson4 offer a Comment on #GenderEquity in science: "...because we need all types of women and people of all gender identities in science". 👉rdcu.be/dwEU nature.com/articles/s4155…

Intriguing perspective in Cell on the future of structural #cellbiology by our Beck Laboratory, Roberto Covino (FIAS), Inga Hänelt and @mixmue (Goethe-Universität), elaborating on novel technologies and the role of #AI towards understanding the cell👉sciencedirect.com/science/articl…

Excited to share our structural snapshots of MZ1-targeted Brd4BD2 ubiquitination in bioRxiv! Alessio Ciulli Centre for Targeted Protein Degradation We use cryo-EM to capture states of the dynamic Brd4BD2-MZ1-(NEDD8)-CRL2VHL-UBE2R-Ub complex 🔗doi.org/10.1101/2024.0…

See how CRLs forge ubiquitin chains on substrates - and degrader-recruited neo-substrate - at high-res! Millisecond polyubiquitylation! #cryoEM #TPD NatureStructMolBiol Max Planck Institute of Biochemistry (MPIB) UNLV College of Sciences 👉shorturl.at/eFS68 Related exciting work from Alessio Ciulli shorturl.at/hNSU5

Super happy to see the final version of our paper on substrate recognition by the ubiquitin ligase HACE1. A heartfelt thanks to my fantastic team, all collaborators, reviewers, and Dimitris Typas NatureStructMolBiol! nature.com/articles/s4159…

Just published! We at the Plaschka Lab dissected the recycling&biogenesis mechanism of the “Heart of the Spliceosome”, the U5 snRNP. Here’s the paper NatureStructMolBiol: nature.com/articles/s4159… and the tweetorial below: (1/13)

Iris fosteriana Aitch. & Baker Mashhad, Iran April 5, 2024 Elevation: 2050m To photograph this one and some other species, we drove around 3,100 kilometers (Shiraz to Mashhad), from the Southwest of Iran to the Northeast. Was it worth it? #iris #iridaceae #botany #wildflowers