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While TGF-β1 signalling pathways are well-characterized across many fibrotic diseases, this investigation is the first to elucidate key TGF-β1 experimental dosing & exposure parameters in primary knee fibroblasts derived from TKA patients. #BJR #Knee ow.ly/hWys50WaE82

The aims of this study is to investigate the correlations among cytokines and regulatory T cells in ankylosing spondylitis patients, and their changes after anti-tumour necrosis factor-α treatment. #Spine #Patients #BJR ow.ly/QycQ50W90UM

Compared with those who had lower dietary selenium intake and lower serum selenium, subjects with higher dietary selenium intake and higher serum selenium had higher bone mineral density. #Biology #Research #Fracture #BJR ow.ly/POU450W91CU

Further analysis of the tenocyte populations revealed ten distinct cell subtypes, highlighting the diversity of tenocytes in human anterior cruciate ligament tissues. #BJR #ACL #Surgery #OrthoTwitter ow.ly/Mxqf50WaENe

Generally, the therapeutic role of hederagenin treatment on epidural scar formation was exerted by regulating SIRT6/PRMT1 axis-mediated endoplasmic reticulum stress & receptor activator of nuclear factor-κB ligand (RANKL) pathway. #BJR #Research #FOAMed ow.ly/hHPH50WcUZP

Enhancing cavity reaming depth is a simple technique to increase the implant primary stability of press-fit uncemented acetabular cupsomponents, while avoiding any excess in periacetabular strain and the associated fracture risk. #BJR #Fracture #Surgeon ow.ly/K73R50WcVM0

Below the critical aggregation parameter, obtaining five tissue specimens is associated with a high probability of detecting infection, but at a higher aggregation level, increasing the number of specimens is rendered ineffective. #BJR #Ortho #Bacteria ow.ly/C8Ar50WcVSJ

Dihydrocaffeic acid was proved to possess the anti-inflammation and anti-cartilage degradation properties in osteoarthritis chondrocytes. #BJR #Osteoarthritis #Inflammation #FOAMed ow.ly/nywG50WeP96

The Latarjet procedure was able to restore the glenohumeral joint kinematics compared to the healthy shoulder. #BJR #Shoulder #Patients #Surgery ow.ly/PE5M50WcUIr

This study investigated the impact of adjacent muscle trauma on segmental fracture healing using recombinant human bone morphogenetic protein-2 via the induced membrane technique. #BJR #Fracture #OrthoTwitter #Trauma ow.ly/wAcN50WeQgC

The benefits of mechanical stimulation in tendon-bone healing may be related to its regulation of macrophage polarization, which mediated mesenchymal stem cell chondrogenesis by transferring transforming growth factor-β1. #BJR #RotatorCuff #Biology ow.ly/NJmq50WePuP

Objective assessment of physical activity was logistically difficult due to patient and data loss. There were no differences with small effect sizes between groups, despite differences in subjective knee pain. #BJR #Robotics #Knee #Arthroplasty ow.ly/xbBI50WcUio

The aim of this investigation was to compare risk of infection in both cemented and uncemented hemiarthroplasty as well as in total hip arthroplasty following femoral neck fracture. #BJR #Infection #Fracture #Trauma ow.ly/pzyH50WePPw

Despite decades of progress, extendable prostheses have shown promising results but still face challenges such as high infection rates, requiring further technological innovation for better outcomes. #BJR #Oncology #Surgery #Research ow.ly/juVC50Whmos

Synovial fluid neutrophil extracellular trap is a novel and ideal synovial fluid biomarker for periprosthetic joint infection (PJI) diagnosis, which could improve PJI diagnosis greatly. #BJR #Infection #Surgery #FOAMed ow.ly/9r8g50Whsuf

The signal transduction mechanism in subchondral bone (SB) is critical to the balance between cartilage and SB. The imbalance of signal transduction in SB will promote the occurrence and development of osteoarthritis. #BJR #Arthritis #OrthoTwitter ow.ly/QePh50WhxZv

This study demonstrates that G-protein-coupled oestrogen receptor-1 maintains proliferation but suppresses chondrocyte hypertrophy in growth plates by upregulating PTHrP/Ihh during early puberty in male and female mice. #BJR #Research #OpenAccess ow.ly/zG6i50WjTOU

Pellino1 (Peli1) has been reported to regulate various inflammatory diseases. This study aims to explore the role of Peli1 in the occurrence and development of osteoarthritis (OA), so as to find new targets for the treatment of OA. #BJR #Osteoarthritis ow.ly/NEhS50WhuYO

Tranexamic acid influences antibiotic efficacy against both planktonic bacteria and biofilms, with effects varying by antibiotic and bacterial strain. #BJR #Infection #OrthoTwitter #Surgeons ow.ly/NtO150WjTR5