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Check out our latest paper in nature! We unveil the fascinating variation of individual polygenic scoring accuracy across the genetic ancestry continuum!

Fantastic talk by ⁦Kristin Boulier⁩ ⁦UCLA Cardiology Fellowship⁩ ⭐️ fellow about her research on polygenic risk scores at ⁦UCLA Health⁩ at #NCYIF23 ⁦NCYIF⁩ ⁦Karol Watson⁩ ⁦Eric H Yang, MD⁩ ⁦Elizabeth Hutchins⁩

UCLA Health⁩ Faculty and former ⁦UCLA Cardiology Fellowship⁩ ⭐️ fellow ⁦Ashley Stein-Merlob, MD⁩ presenting her 🔥 work on mathematical modeling in TTR #amyloid. Very impressive and inspiring work! ⁦Eric H Yang, MD⁩ ⁦Karol Watson⁩ ⁦Kristin Boulier⁩

We love to see former UCLA Cardiology Fellowship now UCLA Health faculty Ashley Stein-Merlob, MD presenting her work on TTR amyloid! #bruinhearts

Incredibly proud of our STAR #bruinhearts @uclaCVfellows/faculty at NCYIF ’23! Kristin Boulier: PRS integration in UCLA Health Elizabeth Hutchins: MBL 🔮 of 👍 #ECMO decannulation Ashley Stein-Merlob, MD: Math modeling in TTR-CA patterns #NickBrownell: GDMT peri-COVID in VA HF pts 1/

Interesting preprint about the proportional predictive value of PRSs for CVD being way higher in ages <55y, where clinical risk factors are rarer and carry less prognostic power medrxiv.org/content/10.110… Similar data previously for other disease outcomes journals.plos.org/plosgenetics/a…

Great work from UCLA Cardiology Fellowship STAR chief #bruinhearts fellow Elizabeth Hutchins presenting her work on MBL approaches in predicting successful ECMO decannulation! #aha23 ativsoftware.com/appinfo.php?pa… #AHA23

Great to showcase this work on lamin heart disease at #AHA23. Subclinical #LMNA variant carriers may have worse myocardial mechanics, higher T2, higher ECV, and more LGE compared to healthy volunteers. Gabriella Captur; James moon LHA @ UCL/UCL Institute of Cardiovascular Science; Barts Health

Grateful for something today? ✅Family re-united ✅Working at Mayo Clinic CV ✅Personal growth ✅Hive support The process was #difficult, but it is only when you’re #vulnerable that you are given the chance to #grow and become more #resilient shorturl.at/hzFNR

Nothing makes me as uneasy as a human geneticist as seeing the proliferation of direct to consumer polygenic risk score companies. I know academics are conservative but these scores are truly not good enough yet & have potential for true harms

Examining the cross-ancestry generalizability of polygenic risk scores, Human Genetics and Genomics Advances' latest study discovered that PGS313 predicts breast cancer risk, but with reduced accuracy, for American women of African, Asian, and Latinx ancestry: cell.com/hgg-advances/f… Bogdan Pasaniuc #ASHG

Strong Department of Medicine at UCLA Health UCLA Cardiology Fellowship representation at #ACCAthleticHeart! Congrats to Daniel Yazdi, MD MS, Martine Webb, Kyle Udd-Guarnica, Kristin Boulier, and Aneeq Malik on their poster presentations at the meeting 🙌🏼 Always happy to have Dr. Prashant Rao crash our UCLA Health gatherings, too 😅

Really nice method for computing context specific polygenic score uncertainty. PRS methods are so far ahead of most clinical scores on this point. nature.com/articles/s4158…

Check out our newest CME/CNE course on interpreting negative and VUS results from cardiac genetic testing created through a partnership with Northwestern Feinberg School of Medicine, The Jackson Laboratory , Sanford Health and Augustana University Help me in spreading the word!  education.clinical.jax.org/page/cardiovas…

Do the multiple existing PRSs offer reliable individual-level assessment of disease risk❓ 👉48 PRSs for coronary artery disease 👉comparable population-level calibration and discrimination ❗️wide variance in individual-level risk depending on PRS 🔗medrxiv.org/content/10.110…

1/ Excited to share this preprint from all-star Sarnoff Foundation fellow Sarah Abramowitz, studying population- and individual-level performance of coronary artery disease polygenic risk scores, co-mentored with Scott Damrauer.

Congrats to UCLA Health #cardioonc #bruinhearts Research Director Ashley Stein-Merlob, MD for receiving her KL2 Translational Science🎀in🔎Computational Modeling of Myocardial TTR Amyloid Deposition! Exciting work coming out from our group! 🙏Alan Garfinkel 4 your mentorship & #UCLASTAR!

🚨 Our work exploring polygenic risk scores for Coronary Heart Disease is now out in JAMA and presented at #AHA24 by all-star Sarnoff Foundation fellow Sarah Abramowitz: jamanetwork.com/journals/jama/…

Now out in JAMA: How well do individual risk estimates from different CHD polygenic scores agree? Grateful to work on this with a dream team of mentors and co-authors Scott Damrauer Michael Levin Bogdan Pasaniuc Dr. Marylyn D. Ritchie, PhD Dokyoon Kim Benjamin Voight Kristin Boulier Karl Keat

Despite similar performance at the population level, different coronary heart disease polygenic risk scores produced highly variable individual-level risk estimates. ja.ma/42gmKCu