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Franken et al. have developed a 3D tissue engineered muscle bundle model to study facioscapulohumeral muscular dystrophy (FSHD). The model recapitulates key pathological hallmarks, including DUX4 expression and reduced absolute contractile forces. tinyurl.com/4d72wad8

Belelli et al. explore the role of GABA in integrating brain and GI tract functions in health and disease. They discuss how gut bacteria use and produce GABA, influencing brain activity and providing potential therapeutic opportunities for brain disorders. tinyurl.com/m525d4he

Computational neuropsychiatry seeks to explain neurological and psychiatric disorders in terms of neuronal message passing. Bottemanne et al. argue that these models may not apply to vascular neurological pathologies and severe tauopathy & synucleinopathy. tinyurl.com/bddu23ve

Lado et al. show in mice that the L444P Gba1 mutation impairs cognition, independent of α-synuclein. When combined with α-synuclein overexpression, the Gba1 mutation interacts with existing α-synuclein pathology, worsening cognitive and motor deficits. tinyurl.com/mauhccnj

I'm planning to write an editorial in Brain entitled "If patients only knew". It's about obstacles that slow down or prevent people from participating in clinical studies and the pace of initiating #ClinicalTrials. If you have experience or comments please message me and RT

Koch & Frey et al. introduce a novel way of analysing brain organisation by integrating neurotransmitter densities with structural connections, and show that damage to dopaminergic pathways has a significant impact on stroke recovery. tinyurl.com/favu8zve

Orthopoxviruses—including mpox and smallpox—cause symptoms such as fever and skin lesions, but can also lead to neurological complications. Miranzadeh Mahabadi et al. review current understanding of orthopoxvirus neuropathogenesis. tinyurl.com/2a8zndh2

Ventriculitis is a life-threatening infection of the ventricular system. In the international VELCRO cohort study, Luque Paz et al. describe the characteristics and outcomes of ventriculitis by underlying aetiology. tinyurl.com/3um7wtu9

New issue of Brain now online! academic.oup.com/brain/issue/14…

Delva et al. show that blood-based tests for AD biomarkers—specifically plasma Aβ42/40 ratio and pTau181—can be used to predict conversion to dementia with Lewy bodies in individuals with idiopathic/isolated REM sleep behaviour disorder. tinyurl.com/4r5jza5z

Emani et al. explore the origin of brain vascular abnormalities known as arteriovenous malformations. They show that these malformations likely form early in childhood, and that annual risk of rupture varies over time and peaks at age 13. tinyurl.com/45v2duru

The LRRK2 activating mutation G2019S is the most frequent genetic cause of Parkinson's disease. Cortés et al. identify elevated phospho-RAB12 levels in blood as an endogenous biomarker of G2019S mutation carriers, with potential utility in clinical trials. tinyurl.com/yc2tkn57

Chiaro et al. describe the long-term natural history of a cohort of patients with isolated autonomic failure. They validate a predictive model based on a cluster of biomarkers that can help identify risk of conversion to more widespread synucleinopathy. tinyurl.com/s5pn5h79

Agosta et al. examine the relationship between network vulnerability and atrophy progression in FTD, using the Network Diffusion Model of pathology spread. They show that the model can accurately predict atrophy evolution. tinyurl.com/58xvhxdm

Using models of prion disease, Homma et al. show that activation of oligoadenylate synthetase 1a (Oas1a)—an interferon-stimulated gene downstream of the type I interferon receptor—suppresses prion invasion at an early stage. tinyurl.com/4newa9mc

Touvier et al. investigate the role of the UPR transcription factor XBP1s in models of proteotoxic Charcot–Marie–Tooth type 1B. Activation of XBP1s limits Schwann cell demyelination – enhancing its activity could be a promising therapeutic approach. tinyurl.com/3n35e3sc

Moquin-Beaudry et al. identify shifts in immune cell subtype abundance and potential gene expression signatures linked to immune activation in patients with Parkinson's disease. tinyurl.com/24kc9edr

Overcoming the dopamine-centric model of impulse control disorders in Parkinson’s disease: the role of 5-HT New scientific commentary by Roberto Cilia & Valtteri Kaasinen tinyurl.com/2ffbndxx

Beyond a syndrome: a mechanism for depression in Parkinson’s disease New scientific commentary by Campbell Le Heron & Trevor TJ Chong tinyurl.com/34u6mnxx

More is more: combining therapies to enhance spinal cord injury recovery New scientific commentary by John Kramer et al. tinyurl.com/54h3pv5y