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Another good news from the lab to start 2021: latest publication - chromatin accessibility and glioblastoma cancer #stemcell. More than genetics & heterogeneity in CSC across primary tumours where one CSC subtype linked to worst outcome. doi.org/10.7554/eLife.… eLife - the journal

Thanks to Peter Dirks Stephane Angers @marcoUofC @RockyMtnBrain Benjamin Haibe-Kains Molly Shoichet, Mike Taylor the #SU2C brain cancer dream team and all others involved.

New work from our Stand Up To Cancer team. GSC states also defined by chromatin openness, including an aggressive invasive type not seen in other data. Led by Mathieu Lupien & Paul Guilhamon w Stephane Angers @marcoUofC @RockyMtnBrain Benjamin Haibe-Kains Molly Shoichet, Mike Taylor. elifesciences.org/articles/64090

Another publication from the lab and Benjamin Haibe-Kains, showing how #epigenetics informs of the genetic architecture of potency from stem to mature cells: Large organized chromatin lysine domains help distinguish primitive from differentiated cell populations disq.us/t/3ubzxex

Out today! our study of PRMT5 inhibitors in GBM disrupt splicing, cell cycle and stemness. Awesome collaboration with Peter Dirks, Structural Genomics Consortium (SGC), Katlin B Massirer, Benjamin Haibe-Kains Mathieu Lupien, and many others @SU2C_Canada Cancer Stem Cell Dream Team. rdcu.be/cfaDG

PRMT5 inhibition disrupts splicing and stemness in glioblastoma | Nature Comm. New paper from our ⁦⁦Stand Up To Cancer⁩ ⁦SU2C Canada⁩ team! Great work with @cherylarrowsm1 Structural Genomics Consortium (SGC)⁩ ⁦@RockyMtnBrain⁩ Benjamin Haibe-Kains Mathieu Lupien nature.com/articles/s4146…

Researchers from SickKids, Princess Margaret Cancer Centre, Temerty Medicine led by Dr. Peter Dirks (pictured in his lab pre-pandemic) have found a promising new approach to stop growth of #braincancer cells. Published today in Nature Communications. Read more: bit.ly/2LIs0Km

#InternationalChildhoodCancerDay Recognizing all the great work being done for high risk childhood cancer The Hospital for Sick Children (SickKids) by Meredith Irwin Uri Tabori vijay ramaswamy, James Rutka Peter Dirks @WBderry David Malkin, CGuidos, JDanska JHitzler

Medicine is a lesser profession without a solid grounding in the humanities nytimes.com/2021/04/10/opi…

Jim Woodgett Sinai Health What determines recognition in science? The good fortune to work with dozens of outstanding trainees, research associates, and international colleagues who collectively help build durable scientific stories that stand the test of time #Reproducibility Science is done by teams

Wishing best of luck to these six outstanding incoming R1s, Eagan, Aaron, Jas, Patrick, Jessica and Mary, ⁦as they start their #neurosurgery journey ⁦University of Toronto Neurosurgery⁩. ⁦gelareh-zadeh⁩ ⁦Sunnybrook Health Sciences Centre⁩ ⁦Unity Health Toronto⁩ ⁦University Health Network⁩ ⁦⁦The Hospital for Sick Children (SickKids)⁩

Very pleased to share our latest paper led by PhD student Akram Hamed and great collab with Ben Simons (U Cambridge) and Lincoln Stein(OICR)! Single cell neural stem cell maps and brain tumor insights! nature.com/articles/s4146…

Congratulations to Peter Dirks and his team and the collaborators!

My first first-author manuscript is now on bioRxiv, thanks to everyone that helped put this together!

Recapitulating cerebellar granule neurogenesis Read this Research Highlight showcasing work from Biren Dave @Birendave, Peter Dirks Peter Dirks and colleagues SickKids Developmental & Stem Cell Biology Program The Hospital for Sick Children (SickKids): journals.biologists.com/dev/article/15…

Read our latest #research on glioblastoma origins and growth, injury-reprogramming to neural crest-like identity, led by Akram Hamed from my lab, with Lincoln Stein,MarioniLab,Benjamin Simons, published with Springer Nature in @nature, rdcu.be/d5n7I

Nature research paper: Gliomagenesis mimics an injury response orchestrated by neural crest-like cells go.nature.com/3DF9uNP

Very pleased to post this new study from my group led by Kinjal Desai, targeting a rare cell fate OLIG2-mediated transition in the medullo hierarchy with CT-179. Preventing stem cell activation!#naturecomm can01.safelinks.protection.outlook.com/?url=https%3A%…

Two world-leading research teams in Australia and North America have shown a potential new targeted therapy for childhood brain cancer effectively kills tumour cells in pre-clinical models. University of Toronto The Hospital for Sick Children (SickKids) Emory University #braincancer #researchforgood #medicalresearch 🧵

Happy to share the “behind the paper” that @kinjaldesai156 and I wrote on our new paper Nature Communications, targeting cell fate transitions in medulloblastoma! Targeting proliferative activation of stem cells blocks tumor formation and regrowth after Rx. communities.springernature.com/posts/targetin…