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Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity: Molecular Cell cell.com/molecular-cell…

The Breakthrough T1D Barbara Dewey Cammett Center of Excellence, led by Dr. David Harlan, consists of scientists from UMass Chan Medical School, The Jackson Laboratory, Harvard Medical School & University of Toronto who are collaborating to develop a T1D cell replacement therapy to evade the immune system. bit.ly/450wMcC

Congratulations to Carey Zammitti, a research associate in the Brehm_Lab_UMassChan. Her son Christopher graduated from T.H. Chan School of Medicine at UMass Chan and was awarded the Chancellor’s Medal for Distinguished Scholarship, the highest honor for his medical class!

#WolframSyndrome is a rare genetic disorder that causes diabetes, vision and hearing loss, and neurological decline. The Wolfram Syndrome International Registry & Clinical Study performs: 🧪 Genetic testing 🩺 Specialized care 🧬 Research Learn more: wolframsyndrome.wustl.edu.

My absolute favorite lab tradition - champagne (mimosa) toasts to a newly accepted paper, celebrating Jin Li's new story! Can't wait to share when it's out in print! 🍾🥳

Douglas A. Melton, Ph.D., Distinguished Research Fellow, Vertex Pharmaceuticals, spoke during the Drug Information Association (DIA)'s Global Annual Meeting this week about the promise of cell therapies and cures for type 1 diabetes (#T1D). Dr. Melton was joined in the session by FDA Commissioner

ADA is here and the Breakthrough T1D team is on site! Day one came with some very exciting news from Vertex on the trials surrounding their drug Zimislecel, also known as VX880. Our Chief Scientific Officer, Dr. Sanjoy Dutta, breaks down the latest updates on where the trial

Big #T1D news! Vertex has published their phase 1–2 trial of stem cell-derived islets (VX880, now called zimislecel). All 12 full-dose patients had reduced insulin need, and 10 no longer require insulin injections. Major step forward to a functional cure! nejm.org/doi/full/10.10…

This afternoon at #ADA2025 Jason Gaglia Joslin Diabetes Center presents #TrialNet research poster 726-P “Two-Year Follow-up of AVT001 Dendritic Cell Therapy for Type 1 Diabetes—Continued Off-Therapy Functional Effects and Characterization of Responders”

Vertex published their stem cell-derived T1D therapy clinical trial with restored islet function for all 14 participants after a single infusion, with 12 achieving A1c <7% and reduced insulin. We are working to make these cells invisible to the immune system UMass Chan Medical School.

Earlier today at the ADA Scientific Sessions, Sana Biotechnology gave an exciting 6-month update on the first person who received transplanted donor-derived pancreatic islet cells modified with hypo-immune (HIP) technology, a cell therapy that does NOT require immunosuppression.

University of Southampton University of Southampton scientists Southampton Medicine and Biological Sciences win two national awards dailyecho.co.uk/news/25270297.…

Megan Orzalli, PhD, assistant professor of medicine at UMass Chan Medical School, has received a PATH award from the Burroughs Wellcome Fund: brnw.ch/21wTPeL The $505,000 award will support Dr. Orzalli’s research on the skin’s immune system. #BWFpath Burroughs Wellcome Fund Department of Medicine

Thanks to all of my colleagues, both in and out of my department/center/university Johns Hopkins University Johns Hopkins Engineering Translational Tissue Engineering Center The Johns Hopkins Institute for NanoBioTechnology, who’ve helped support. It’s an honor to work with and be counted among you. 👊

Thank you MATTEL for creating a #Barbie with #Type1Diabetes, wearing a CGM & insulin pump. It was developed in partnership with Breakthrough T1D to empower children with #T1D to see themselves reflected in their toys. 👋nbcnews.com/health/kids-he…

Meet our summer interns in the Brehm_Lab_UMassChan. Both juniors on pre-med tracks; Emma (left) at @HighPntStudents is majoring in biology and Spanish; Nithila is a biology & social science major at New York University Shanghai. They appreciate hands-on experiences and the knowledge gained!

Read Pukkila-Worley, MD, is the new director of the MD/PhD program: direc.to/n8PN Dr. Pukkila-Worley has mentored dozens of MD/PhD graduate students since joining UMass Chan Medical School in 2014. The Pukkila-Worley Lab is also @rpwlab.bsky.social studies host-pathogen interactions and bacterial pathogenesis. UMass Chan MD/PhD Program

It finally happened! Congrats to Kat Murphy and Jessica Peura on officially receiving their F31 fellowships! Very proud of both of you and could not be more deserving. NoA dreams still do come true.

Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔 🚨In new work out today in Nature Metabolism, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s4225… 1/n

Human pancreatic islets exposed to cytokines alter the way islet cells display antigens to the immune system, according to this Type 1 diabetes research published in Cell Reports by UMass Chan Medical School scientists. umassmed.edu/dcoe/news/umas…