𝗧𝗵𝗲 𝗚𝗲𝗻𝗼𝗺𝗶𝗰 𝗖𝗼𝗱𝗲 - 𝘁𝗵𝗲 𝗴𝗲𝗻𝗼𝗺𝗲 𝗶𝗻𝘀𝘁𝗮𝗻𝘁𝗶𝗮𝘁𝗲𝘀 𝗮 𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗶𝘃𝗲 𝗺𝗼𝗱𝗲𝗹 𝗼𝗳 𝘁𝗵𝗲 𝗼𝗿𝗴𝗮𝗻𝗶𝘀𝗺 🧬 arxiv.org/abs/2407.15908- very excited to share this new preprint from me and Nick Cheney 😀🧵

Need to design your next Xenium/CosMx/Merfish experiment? Spapros, now out Nature Methods, allows for probe set selection for target spatial tx. Led by Louis Kuemmerle, it optimizes both cell type ID & within-cell type variation. nature.com/articles/s4159… github.com/theislab/spapr…

It's my pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture. If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. nature.com/articles/s4158…

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time

🚨 Exciting news! 🚨 Our latest paper is now published in Science Advances! 🎉 "Transcription-coupled changes in genomic region proximities during transcriptional bursting" 👉 Read it here: science.org/doi/10.1126/sc…

We think of our own, biological memory the way we think of computer memory: the more, the better. But that’s not what evolution intended when it created learning. Learning is not just about storing information: it is about choosing what to store and what to discard. 🧵/1

Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of Jon Markert tinyurl.com/setd2

In our SETD2 paper, we visualize a novel nucleosome transfer intermediate during txn. It is the earliest intermediate visualized yet. In the intermediate, the histone chaperone FACT coordinates histone binding with a previously uncharacterized RTF1 helix: tinyurl.com/setd2

nature.com/articles/s4158… (1/n) Ever wonder how transcription factors locate, "invade," and activate their enhancers during cell fate acquisition? 🧬🚀Check out our latest collaborative work with the Soufi lab, now published in nature!

Our ChromBPNet preprint out! Huge congrats to Anusri Pampari! This was quite a slog for both of us but we r very proud of this one! It is a long read but worth it IMHO. Methods r in the supp. materials. Link in the next tweet. Bluetorial coming soon .. 1/

🎇🎄Some holiday reading: Overdue TWEETORIAL on the latest preprint from our lab. 🎇🎄 In this work, superstar postdoc Xinhe Xue combined 2 kinds of pooled CRISPR screens to pinpoint noncoding regulatory elements and the transcription factors that activate these elements.

An #OpenAccess review on current status of KRAS inhibitors, resistance drivers & potential combinations from Der Lab at UNC Channing Der Bjoern Papke & colleagues DKFZ Charité - Universitätsmedizin Berlin in Trends in Cancer As always very informative illustrations: A: Frequency of KRAS Allelic alterations across

TurboCas: A method for locus-specific labeling of genomic regions and isolating their associated protein interactome dlvr.it/TH6S6r

STIM1-mediated NFAT signaling synergizes with STAT1 to control T-bet expression and TH1 differentiation nature.com/articles/s4159… Nature Immunology Feske lab at NYU

Inverse signal importance in real exposome: How do biological systems dynamically prioritize multiple environmental signals? biorxiv.org/content/10.110… #biorxiv_bioinfo

Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ Jan Philipp Kreysing, Johannes Betz,Turoňová lab, Marina Lusic, Hummer lab, Beck Laboratory, Max Planck Institute of Biophysics 🔗 Preprint here: doi.org/10.1101/2025.0…

Beyond excited to share our #NewPaper in Cell! Inflamed environments acidify intracellular pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of inflammation. #inflammation #pH authors.elsevier.com/sd/article/S00…

Excited to share our new Molecular Cell paper! We show that β-catenin is an adaptor that links canonical BAF (cBAF) with binding partners via IDR-domain interactions. (1/7) cell.com/molecular-cell…

I'm excited to share our new preprint on LagTag, a method that recovers both past and present chromatin states from the same mammalian cells. biorxiv.org/content/10.110…