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The people ripping Wendy’s for this don’t understand basic economics, just like the people who ripped Uber didn’t. Higher prices serve a signal to all of the burgers that would otherwise choose to stay home to come get eaten when demand is highest.

“In the poorest 1% of zip codes that have lottery retailers, the average American adult spends around $600 a year, or nearly 5% of their income, on tickets. That compares with just $150, or 0.15%, for those in the richest 1% of zip codes.” economist.com/graphic-detail…

Just spent $460 on a plane ticket that costs $210 if booked outside the institution’s travel site…presumably this is in the name of being good stewards of NIH funds…

Simpson’s Paradox is a fascinating statistical phenomenon where the relationship between two variables can completely change when a third variable is considered. This often leads to contradictory conclusions if not carefully analyzed. For example, in a data set, you might see a

Mmmm ... this is a weird critique IMO. If methods are described in detail in a different document that does justice to it, I am not sure what the problem is. I once published a paper with a 200 page supplement with very detailed methods. 1/

Do grant proposal texts matter for funding decisions? A field experiment Spoiler alert...NO! #Grants #academia

THIS is the gap between the real harms Americans face, what we worry about, and what the media covers. Ugh.

Kind of a big deal: GPT-4 simulates people well enough to replicate social science experiments with high accuracy Note this is done by having the AI prompted to respond to survey questions as a person given random demographic characteristics & surveying thousands of "AI people"

This is awesome. We are at the point where an easily computed polygenic score for ascending aortic diameter is the best feature in a model predicting it.

AI provides a universal framework that leverages data and compute at scale to uncover higher-order patterns Today, Arc Institute in collaboration with NVIDIA releases Evo 2—a fully open source biological foundation model trained on genomes spanning the entire tree of life 🧵

$PLTR CEO Dr. Alex Karp 🔮🔥 “You need a higher purpose, and I think you often need a lower purpose. Andrew Ross Sorkin: “what’s your lower purpose” Karp: “I love the idea of getting a drone and having light fentanyl-laced urine spraying on analysts that tried to screw us”

MI-GENES randomized patients at intermediate cardiovascular risk to disclosure of framingham risk score 🆚an integrated score also incuding a polygenic risk score (PRS)🧬 Disclosing the PRS led to 👉lower LDL 👉higher statin initiation 👉lower 10-y cardiovascular event rates

14% of 55-69 men with polygenic risk scores (PRS) in the top 10% had prostate cancer classified as intermediate or higher risk, a higher percentage than would have been identified using PSA or MRI screening. This seems like a strong argument for integrating polygenic risk scores

Will prostate cancer screening be the first clinical use case for a polygenic risk score (PRS)? In the BARCODE1 study (European men aged 55-69y), a PRS in >90th percentile detected more intermediate/high risk cancers needing treatment than MRI or PSA NEJM

Derek Lowe is right that Demis Hassabis is wrong - there is no chance of curing all disease within the decade. Even if we had AGI now, we wouldn't do it. We lack the basic knowledge and need to keep doing experiments. science.org/content/blog-p…

All concepts from physics to language are socially constructed and many of them still refer to things that have an underlying reality. Despite there being no contradiction between "socially constructed" and "real", many people think social construction precludes reality.

The figure in this article illustrates exactly how most biology papers are secretly p-hacked. A large number of hypotheses is explored, and only the ones that form a coherent story are reported. This is actually the main reason behind the replication crisis in biology IMO.

has anyone stopped to ask WHY students cheat? would a buddhist monk "cheat" at meditation? would an artist "cheat" at painting? no. when process and outcomes are aligned, there's no incentive to cheat. so what's happening differently at colleges? the answer is in the article:

Beautiful work demonstrating how common variants modify the penetrance of rare variants in both children and adults with telomere biology disorders (TBDs). According to the liability threshold model, rare and common variants additively raise disease risk beyond a threshold,