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Integrating Spatial and Single-Nucleus Transcriptomic Data to Assess the Effects of Intrauterine Hyperglycemia on Fetal Pancreatic Development. advanced.onlinelibrary.wiley.com/doi/10.1002/ad…

GLP-1R/GCGR dual agonism dissipates hepatic steatosis to restore insulin sensitivity and rescue pancreatic β-cell function in obese male mice #diabetes #obesity #MASLD Nature Communications nature.com/articles/s4146…

New content online: Diabetes mellitus and the key role of endoplasmic reticulum stress in pancreatic β cells bit.ly/3ZhpTzR

Precision Diabetes and Diet: Our Nature Medicine Paper showing people with different subphenotypes associated with diabetes spike their glucose to different carbs: doi.org/10.1038/s41591…

Scale up manufacturing approach for production of human induced pluripotent stem cell-derived islets using Vertical Wheel® bioreactors. nature.com/articles/s4153…

Senescence-resistant human mesenchymal progenitor cells counter aging in primates cell.com/cell/abstract/…

Excited to share our latest findings today at 2 PM! We uncover how mitophagy regulates β-cell identity and immunogenicity in T1D. Looking forward to great discussions on diabetes research—see you there!

A novel CD3ε fusion receptor allows use of T-cell engagers on TCR-less allogeneic CAR T cells to improve activity and prevent antigen escape dlvr.it/TLTFQg #genetherapy #celltherapy

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes. nejm.org/doi/full/10.10…

The RNA-binding E3 ligase MKRN2 selectively disrupts Il6 translation to restrain inflammation. nature.com/articles/s4159…

scRiskCell: A single-cell framework for quantifying islet risk cells and their adaptive dynamics in type 2 diabetes. onlinelibrary.wiley.com/doi/10.1002/im…

BRD4 Signaling Maintains the Differentiated State of β Cells - Liu - Advanced Science - Wiley Online Library. advanced.onlinelibrary.wiley.com/doi/10.1002/ad…

Thrilled to share our latest work in nature studying inter-brain neural dynamics in both biological and artificial intelligence systems — amazing work by Xingjian_Zhang 🧠, Nguyen Phi, and fantastic collaboration with Jonathan Kao! Read the full article here: rdcu.be/euu5Z

New single-nucleus and spatial datasets offer unprecedented insights into the basis of #obesity associated adipose tissue dysfunction and its reversal by #weightloss and are a key resource for mechanistic and therapeutic exploration nature.com/articles/s4158…

During obesity, the bone marrow is dysregulated to overproduce myeloid cells that drive systemic inflammation. Quin Waterbury, Timothy Wang et al. Herbert Irving Comprehensive Cancer Center show that neutrophil migration is a key mediator of this process. hubs.la/Q03x3Z2b0

Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication. cell.com/cell-metabolis…

Lymphatic endothelial cell S1P/S1PR1 signaling plays a role in mesenteric TLS formation in the absence of subclinical inflammation and, importantly, is a key regulator of lymphatic valve development rupress.org/jem/article/22… Journal of Experimental Medicine rupress.org/jem/article/22…

New! Online now: Shivering, but not adipose tissue thermogenesis, increases as a function of mean skin temperature in cold-exposed men and women dlvr.it/TLy1qc

Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔 🚨In new work out today in Nature Metabolism, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s4225… 1/n