Paul Bröckelmann (@broeckelmannpj) 's Twitter Profile
Paul Bröckelmann

@broeckelmannpj

Physician Scientist @UKKoeln & @MPIAGE. Hemato-Oncology, Lymphoma, Immunotherapy. Views are mine & no advise, RT/like no endorsement. COI: bit.ly/34MaLOt

ID: 1209011263

linkhttp://innere1.uk-koeln.de calendar_today22-02-2013 15:48:53

1,1K Tweet

962 Followers

107 Following

ASH (@ash_hematology) 's Twitter Profile Photo

The #ASH24 abstracts are live! See the amazing scientific breakthroughs being presented at the ASH annual meeting. View them now: ow.ly/szvb50U0j7Y Experience the science in San Diego or virtually. Registration is still open!

The #ASH24 abstracts are live! See the amazing scientific breakthroughs being presented at the ASH annual meeting. 

View them now: ow.ly/szvb50U0j7Y

Experience the science in San Diego or virtually. Registration is still open!
Paul Bröckelmann (@broeckelmannpj) 's Twitter Profile Photo

Great study of irMyocarditis nature, which appears to be mediated by DCs, cycling CD8 T cells and CXCR3-L expressing fibroblast subsets in the tissue. Interestingly, expanded T cell clones were shared between blood and heart but not the tumor. Many more important insights 👀

Great study of irMyocarditis <a href="/Nature/">nature</a>, which appears to be mediated by DCs, cycling CD8 T cells and CXCR3-L expressing fibroblast subsets in the tissue. Interestingly, expanded T cell clones were shared between blood and heart but not the tumor. Many more important insights 👀
Paul Bröckelmann (@broeckelmannpj) 's Twitter Profile Photo

Important observation, highlighting the need to not only reduce radiotherapy but also anthracycline exposure in (Hodgkin) lymphoma treatment. Need to tailor treatment to individual risk and re-evaluate cardioprotective measures.

Gareth Gregory (@drgarethgregor1) 's Twitter Profile Photo

Delighted to share the practice-changing #STARGLO study manuscript at The Lancet today. Transplant-ineligible DLBCL should no longer be considered a palliative scenario #lymsm Glofitamab plus gemcitabine and oxaliplatin (GemOx) versus rituximab-G... sciencedirect.com/science/articl…

Eddie Cliff (@eddie_cliff) 's Twitter Profile Photo

Just out JAMA Oncology led by ErfanParsa We review why many efforts to improve access to oncology medicines around the world have failed so far, especially compared to infectious diseases, & offer potential strategies to improve global pharmacoequity jamanetwork.com/journals/jamao…

Just out <a href="/JAMAOnc/">JAMA Oncology</a> led by <a href="/ParsaErfan/">ErfanParsa</a> 

We review why many efforts to improve access to oncology medicines around the world have failed so far, especially compared to infectious diseases, &amp; offer potential strategies to improve global pharmacoequity

jamanetwork.com/journals/jamao…
Paul Bröckelmann (@broeckelmannpj) 's Twitter Profile Photo

Really looking forward to contributing to the first UK Hodgkin Lymphoma forum in February 2025. Exciting times with a lot of opportunities for collaboration for the benefit of our patients.

Alexandra-Chloé Villani Lab (@villanilab) 's Twitter Profile Photo

⭐️NEW PAPER OUT in nature⭐️ 🫀What is the relationship between the immune responses in the heart, blood, and tumor in patients with inflammation in the heart resulting from cancer immunotherapy (irMyocarditis)? This 🧵 breaks down the key findings 1/n nature.com/articles/s4158…

Nature Medicine (@naturemedicine) 's Twitter Profile Photo

In the dose escalation phase of the ongoing #LIBRA4Trial, patients with relapsed/refractory peripheral T cell #lymphoma were treated with TRBC1-targeted CAR #TCellTherapy, showing limited toxicity and promising early clinical responses. nature.com/articles/s4159…

NEJM (@nejm) 's Twitter Profile Photo

The combination of nivolumab and ipilimumab in patients with metastatic colorectal cancer led to 24-month progression-free survival of 72%, as compared with 14% with chemotherapy. Read the full CheckMate 8HW trial results: nej.md/4eGp1tj

The combination of nivolumab and ipilimumab in patients with metastatic colorectal cancer led to 24-month progression-free survival of 72%, as compared with 14% with chemotherapy. Read the full CheckMate 8HW trial results: nej.md/4eGp1tj
Paul Bröckelmann (@broeckelmannpj) 's Twitter Profile Photo

How do ageing and age-associated changes of the immune landscape affect immunotherapies in patients with lymphoma or multiple myeloma? Very happy to see our comprehensive review of the available evidence lead by Fabian Ullrich & Nina Rosa Neuendorff out Journal for ImmunoTherapy of Cancer 🎉 jitc.bmj.com/content/12/12/…

How do ageing and age-associated changes of the immune landscape affect immunotherapies in patients with lymphoma or multiple myeloma? Very happy to see our comprehensive review of the available evidence lead by <a href="/fa_ulle/">Fabian Ullrich</a> &amp; <a href="/neuendorff_nr/">Nina Rosa Neuendorff</a> out <a href="/jitcancer/">Journal for ImmunoTherapy of Cancer</a> 🎉 jitc.bmj.com/content/12/12/…
Paul Bröckelmann (@broeckelmannpj) 's Twitter Profile Photo

Nice real-world data on the safety and efficacy of low-dose nivolumab from Monterrey 🇲🇽 Similarly high response rates and survival with lower doses of 40-140mg Q2W instead of 240mg in the pivotal CM205 study in this single-center cohort (N=27): tinyurl.com/569krdzb

Nice real-world data on the safety and efficacy of low-dose nivolumab from Monterrey 🇲🇽 Similarly high response rates and survival with lower doses of 40-140mg Q2W instead of 240mg in the pivotal CM205 study in this single-center cohort (N=27): tinyurl.com/569krdzb
Paul Bröckelmann (@broeckelmannpj) 's Twitter Profile Photo

Happy to be back in San Diego for #ASH24🩸🌞🌴🌮 Looking forward to a lot of exciting science, impactful data and exchange with international colleagues and friends

Happy to be back in San Diego for #ASH24🩸🌞🌴🌮 Looking forward to a lot of exciting science, impactful data and exchange with international colleagues and friends
Lymphoma Hub (@lymphomahub) 's Twitter Profile Photo

CONGRESS | #ASH24 | Justin Ferdinandus Justin Ferdinandus Uniklinik Köln shares results from the phase II portion of the GHSG HD21 trial of PET-guided BrECADD in older patients with advanced-stage cHL. At a median FU of 23 mo, 12 mo PFS 95.1%, 24 mo PFS 91.5, 12 mo OS 96.2%, 24 mo OS

CONGRESS | #ASH24 | Justin Ferdinandus <a href="/jusferdinandus/">Justin Ferdinandus</a> <a href="/UKKoeln/">Uniklinik Köln</a> shares results from the phase II portion of the GHSG HD21 trial of PET-guided BrECADD in older patients with advanced-stage cHL. At a median FU of 23 mo, 12 mo PFS 95.1%, 24 mo PFS 91.5, 12 mo OS 96.2%, 24 mo OS
Raul Cordoba, MD, PhD (@drraulcordoba) 's Twitter Profile Photo

🚨 HOT OFF THE PRESS!! Impact of immunological #aging on T cell-mediated therapies in older adults 👴👵 with multiple #myeloma and #lymphoma #hematology 🩸 #lymsm #mmsm #ImmunoOnc search.app/vHF2CdrQUKDVq3…

Lymphoma Hub (@lymphomahub) 's Twitter Profile Photo

Catch up on our panel discussion on sequencing targeted therapies for cHL, chaired by @gilles_salles, Memorial Sloan Kettering Cancer Center, and joined by Ann LaCasce, MD, Harvard Medical School, and Paul Bröckelmann, Uniklinik Köln. Watch the full video here: loom.ly/G_SLHdI #lymsm #MedEd #ESHLYMPHOMA2024

Paul Bröckelmann (@broeckelmannpj) 's Twitter Profile Photo

Congrats to Nicole Seifert Uni Göttingen & Wolfram Klapper Universitätsklinikum Schleswig-Holstein who spearheaded our TCRseq study in Hodgkin lymphoma Leukemia Journal. Exclusion of clonally expanded T-cells from the TME as a mechanism of immune evasion during anti-PD1 treatment? nature.com/articles/s4137…

Congrats to Nicole Seifert <a href="/uniGoettingen/">Uni Göttingen</a> &amp; Wolfram Klapper <a href="/UKSH_KI_HL/">Universitätsklinikum Schleswig-Holstein</a> who spearheaded our TCRseq study in Hodgkin lymphoma <a href="/LeukemiaJnl/">Leukemia Journal</a>. Exclusion of clonally expanded T-cells from the TME as a mechanism  of immune evasion during anti-PD1 treatment? nature.com/articles/s4137…
Paul Bröckelmann (@broeckelmannpj) 's Twitter Profile Photo

📄📣 Analyzing >10,000 patients treated in randomized GHSG trials, we show strong correlation of PFS and OS after Hodgkin lymphoma first-line treatment across risk groups Annals of Oncology doi.org/10.1016/j.anno…! Great GHSG team effort Bastian von Tresckow Uniklinikum Essen Uniklinik Köln 🎉

📄📣 Analyzing &gt;10,000 patients treated in randomized GHSG trials, we show strong correlation of PFS and OS after Hodgkin lymphoma first-line treatment across risk groups <a href="/Annals_Oncology/">Annals of Oncology</a> doi.org/10.1016/j.anno…! Great GHSG team effort <a href="/B_von_Tresckow/">Bastian von Tresckow</a> <a href="/UniklinikEssen/">Uniklinikum Essen</a> <a href="/UKKoeln/">Uniklinik Köln</a> 🎉
Paul Bröckelmann (@broeckelmannpj) 's Twitter Profile Photo

Thanks for the shout-out and support, Raul Cordoba, MD, PhD! Grateful European Hematology Association for the opportunity to strengthen European collaboration and gain further insights into the biology of Hodgkin lymphoma in older patients to explore novel therapeutic approaches. 🩸🧫🧑‍🔬🇪🇺