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Nature research paper: Enterococci enhance Clostridioides difficile pathogenesis go.nature.com/3hLbYz6

This could help to explain some clinical facts….

▶️ Cephalosporin use is a risk factor for C difficile ▶️ Cephalosporins don't kill enterococci ▶️ Enterococci support growth of C difficile (this is the ⭐new⭐ data nature 👇) #microbiome #antimicrobialstewardship nature.com/articles/s4158…

This class is super helpful and you couldn't find a better instructor than Daniel Beiting!

Helping C. difficile to thrive This study reports that Enterococcus species can remodel the metabolic environment in the gut and reprogramme the metabolism of Clostridioides difficile, enhancing its fitness and virulence. nature.com/articles/s4157…

To start, I want to share one of the coolest papers to come out in nature in years (I might be biased...) from microbiology student Alex Smith from Joe Zackular lab! A terrific demonstration of top notch microbial pathogenesis and genomics research at Penn 🎉

Well, twitter friends, it's official: I'm staying in academia and in Philly, starting as a #newPI on the tenure track in Penn Medicine's Department of Medicine, Division of Translational #Medicine and Human #Genetics 😃🍾🧬

Hello Science Twitter! Really excited to share a short tweetorial of some of my work as a grad student in the Joe Zackular lab at Penn/CHOP focused on the impact of NSAIDs during C. difficile infection: science.org/doi/10.1126/sc…

Alexander Smith Alex Smith from the Zackular lab Joe Zackular defends tomorrow!!

Thrilled to have this story out in mBio and start to answer the question of how enterococci thrive in the CDI gut with an amazing group of collaborators! Spoiler: it uses heme!

And thanks to a great mentor Joe Zackular for supporting me and giving me the opportunity to spread my wings! AZ here we come!

I’m proud to share our recent publication describing the development of a multivalent mRNA-LNP vaccine for C. difficile that incorporates targets across C. diff’s complex life cycle science.org/doi/10.1126/sc…

Delighted to share our work developing an mRNA vaccine for C. difficile, published today in Science Magazine. This study with The Drew Weissman Lab was co-led by two truly amazing scientists: Alexa Sem from the Zackular lab and Mohamad-Gabriel Alameh (now at CHOP Research)! science.org/doi/10.1126/sc…