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Want a quick read on the role of architectural RNA in chromatin organization? Here is our recent review doi.org/10.1042/BST201…… Portland Press

BREAKING NEWS: The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”

Our new paper is out at Science Advances: advances.sciencemag.org/content/6/42/e… Using single-molecule imaging and tracking, Satoru Ide et al. revealed how rRNA transcription is regulated by phase separation in the nucleolus. Congrats, Satoru!　(1/2)

The chemotherapeutic agent CX-5461 irreversibly blocks RNA polymerase I initiation and promoter release to cause nucleolar disruption, DNA damage and cell inviability academic.oup.com/narcancer/arti…

Ribosomal RNA Transcription Regulation in Breast Cancer mdpi.com/1052164

Congratulations to Gerald Tiu and Craig Kerr who co-led this study. With contributions from Olena Zhulyn, @LeilaShokat and Laura Attardi, Davide Ruggero labs. A new role for p53 in embryonic development and ribosomopathies! authors.elsevier.com/a/1dNDf5Sx5gmJ…

Excited that this preprint is out! I'm so grateful that i had the opportunity to work alongside you all on this project! Carson J Bryant Mason McCool Susan Baserga

Excited to share our new work out online today Molecular Cell. Postdoc Zhenkun Na adapted proximity biotinylation to generate a subcellular map of the unannotated proteome. authors.elsevier.com/a/1fUa43vVUPK8…

Human large ribosomal subunit assembly factor proteins, RSL24D1 and the PeBoW complex, are required to maintain normal RNA polymerase I function bit.ly/3iFbqeH

Yay! Excited for all that lies ahead! 🔬

Fantastic to have our paper "Deciphering cell states and genealogies of human hematopoiesis" published today in nature as an Accelerated Article Preview! We describe ReDeeM! Awesome work led by Chen Weng in a wonderful collaboration with Jonathan Weissman's Lab! nature.com/articles/s4158…

Online Now! An iron rheostat controls hematopoietic stem cell fate dlvr.it/T36Hpj #stemcells

Super-excited to share our latest work Cell Stem Cell, unraveling the mitochondrial NADPH-cholesterol axis for EV biogenesis, guiding precise HSC fate! Huge congrats to Massimo Massimo BONORA, Claudia Claudia Morganti, and Nick Nick van Gastel! EinsteinSCI bit.ly/48PuICm

Drs. Richard Piszczatowski MD, PhD, Hannes Buelow (Buelow Lab), & Uli Steidl summarize the roles of HSPGs, heparan sulfate (HS), and HS modifications within each main #hematopoietic cell lineage of both #myeloid and #lymphoid arms in this comprehensive review. 💡 bit.ly/3JvZ8zq

Amazing talk by Uli Steidl on targeting stem cell transcription dynamics at the #MYELOID2024 meeting at Cincinnati Albert Einstein College of Medicine - Official EinsteinSCI

There are few words expressing my joy, awe & admiration for this group. They have solved a 20+ year-long, seemingly impossible challenge: generating transplantable hematopoietic stem cells from human pluripotent cells. Just... WOW. nature.com/articles/s4158… 🤩 AndrewElefanty

Super thrilled to share our article on pharmacological PU.1 repositioning published in Nature Genetics today! Massive thanks to everyone involved! Article -> nature.com/articles/s4158… A digestible PUree of the main findings (aka Research Brief) -> nature.com/articles/s4158…

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

Overwhelmed by all of the exciting advancements surrounding chromatin modifiers in AML? Do you find it hard to keep track of all the new menin inhibitors? Well good news, we’ve just published the perfect review for you in STEM CELLS Translational Medicine academic.oup.com/stcltm/advance… Kira Gritsman

I am deeply honored and immensly grateful to the scientific community at ISEH for receiving this award! And a big shoutout and thank you to all the brilliant and hard-working former and current members of my lab who made the progress possible that led to this award! 😊 🙏