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Therapeutic potential of RNA-enriched Extracellular Vesicles 1: The next generation in RNA delivery via biogenic nanoparticles dlvr.it/T3KXkn #genetherapy #celltherapy

📈 Trending Article in PNAS One of the most-viewed PNAS articles in the last week is “Bodily maps of emotions.” Explore the findings here: ow.ly/q9wZ50QIfCQ For more trending articles, visit the PNAS homepage at ow.ly/egAH50QIfCW.

The OrganiX microfluidic system to recreate the complex tumour microenvironment dlvr.it/T3L8Gt

New Research: Peritumoral brain zone in glioblastoma: biological, clinical and mechanical features: Glioblastoma is a highly aggressive and invasive tumor that affects the central nervous system (CNS). With a five-year survival rate of only… frontiersin.org/articles/10.33… #immunology

Online Now: Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients dlvr.it/T3RPD7

Nature research paper: Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance go.nature.com/3SV1jAW

Neurons (🟠) and microglia (🔵), brain's immune cells! Check the number of microglia available for each neuron. That's because this photo was taken in the cerebral cortex 🧠🔬. In humans, the glia-to-neuron ratio in the cerebral cortex is 3.72 (72% glia), while that in the

You need to be no expert to see the difference between the images below. Normal vs. angry microglia (🟣Iba1 marker) and how they interact with neurons (🟢Neun marker) when something wrong happens. This is one of the sides of neuroinflammation. #Alzheimer

From animal testing to in vitro systems: advancing standardization in #MPS Led by Darwin Reyes National Institute of Standards and Technology & Nureddin Ashammakhi MSU College of Human Medicine, featuring multidisciplinary leaders from U.S. FDA/@EUCouncil/academia/industry pubs.rsc.org/en/content/art… 📚 Reviews issue - pubs.rsc.org/en/journals/jo…

New preprint from Lowe Lab showing how the interplay between canonical genomic alterations like SMAD4 loss & tissue resident epigenomic drivers (KLF4, RUNX1) impacts tissue specific metastatic behavior (liver versus lung). biorxiv.org/content/10.110… dana_peer Chris Iacobuzio

I love this illustration so much. 🤩 It’s a veritable roadmap for program setting in cancer research. Outstanding job by the all 🌟 crew of authors. cell.com/cell/fulltext/…

New experiments uncover how cancer-associated fibroblasts shape the #tumor microenvironment by “donating” packages of proteins to surrounding cells—hinting that disrupting these communication lines might yield therapeutic benefits. @SciSignal scim.ag/6q7

In the latest issue! Cancer biomarkers: Emerging trends and clinical implications for personalized treatment dlvr.it/T4yFdY

The first clinical trial using a mRNA-nanoparticle to deliver a protein replacement, which gets into liver cells and restores mitochondrial function. For a life-threatening, ultra-rare disease that has no treatment. New nature, with results in 16 patients nature.com/articles/s4158…

Inflammation is a common feature of many human diseases. A special issue of Science highlights recent advances in our understanding of #inflammation, especially its role in homeostasis, cell death, viral infection, and more. Read more on #WorldHealthDay: scim.ag/6vg

#PancreaticCancer-associated fibroblasts modulate macrophage differentiation via sialic acid-Siglec interactions nature.com/articles/s4200…

Online Cancer Cell The crosstalk between macrophages and cancer cells potentiates #PancreaticCancer cachexia By Min Li & colleagues OU Health Stephenson Cancer Center cell.com/cancer-cell/fu…

ICYMI: I have always been bothered by the fact that the vast majority of patients diagnosed with #PancreaticCancer have no single attributable risk factor. How can we identify more of such at-risk individuals BEFORE they get diagnosed, often with advanced stage disease? Grateful

Narayanan, V., Schappell, L. E., Mayer, ..., Gleghorn, J. P., & Conway, D. E. (2020). Osmotic Gradients in Epithelial Acini Increase Mechanical Tension across E-cadherin, Drive Morphogenesis, and Maintain Homeostasis. Current Biology, #EpithelialMechanics doi.org/10.1016/j.cub.…

This is a neat idea for many organ-on-chip platforms 👍