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The shikimate pathway is a metabolic powerhouse to all sorts of important compounds across the tree of life. Check out our labor-of-love review Nat. Prod. Reports with Kate Bauman & Vikram Shende - pubs.rsc.org/en/content/art…

Marine natural products - now published in Natural Product Reports pubs.rsc.org/en/content/art…

Is everything bigger in #Texas?? Me & Bradley Moore are stoked to unveil the “PKZILLAs”: Genes for the new largest known enzymes and proteins in #biology, from the Texan fish-killing alga Prymnesium parvum. PKZILLAs make their giant 90-carbon polyketide toxin, prymnesin! 🧵1/n

Move over titin... introducing PKZILLA as the largest protein in life that makes one the largest nonpolymeric compounds in biology, the marine polyether toxin prymnesin. Congrats to Tim Fallon, PhD @[email protected] & Vikram Shende and rest of team! biorxiv.org/content/10.110…

Pleased to share our new ACS Synthetic Bio paper on minor #cannabinoid bioproduction and #biocatalysis led by Anna Love and Trevor Purdy and supported by NIH NCCIH pubs.acs.org/doi/full/10.10…

Finally! After a long journey our latest NRPS engineering story is out at science.org/doi/10.1126/sc… thanks to the hard work of several members from the @HelgeBode_lab

An amazing team effort brings us one step closer cracking the nut of #polyketidesynthase reprogramming. In our new paper published in Science Magazine, we shed light on #Engineering these multimodular assembly lines used for #naturalproduct #biosynthesis. science.org/doi/10.1126/sc…

New group day: We are more than happy to officially welcome Florian Hubrich (Florian Hubrich) and his team to the HIPS family. 🤩 Check out his new website, to learn more about his research: helmholtz-hips.de/en/research/te…

Published today: Finding the truth in science In a ‘publish or perish’ culture, some scientists may resort to questionable research practices or even fraud. nature.com/articles/s4156…

Tired of isolating the same natural products from the same old bacteria?? Well we have the solution for you, SMIRC is here!!! But seriously a monumental effort led by AlexB out of the Jensen Lab Scripps Institution of Oceanography 💊🦠🌊 nature.com/articles/s4146…

Full story here: press.asimov.com/articles/flowe… Lovingly edited by Niko McCarty. and Xander Balwit.

It came from the deep(ish) ocean... and then transitioned to a euryhaline lifestyle causing widespread fish-killing blooms in brackish water throughout Texas and Europe... It's Prymnesium parvum and their #PKZILLA s! Now in Science Magazine science.org/doi/10.1126/sc… Thoughts in:🧵

It was an honor to be a part of this. It was a GIANT team effort and I'm incredibly proud of this work and everyone involved. A big highlight for me was getting to work with my officemate Tim Fallon, PhD @[email protected] to divine how these GIANT enzymes generate these GIANT molecules.

Unique highly hetero-substituted benzenes are defence compounds from tiny springtails. The minute amounts available needed the combination of GC/MS, GC/IR, DFT-calculation, and synthesis to arrive at the structures. Chem. Sci. doi.org/10.1039/D4SC03…

Bacteria are talented producers of #diterpenes. We screened 334 terpene synthases: doi.org/10.26434/chemr…. New skeletons, new stereoisomers, terpenes known in other organisms but new to bacteria. A massive team effort led by Xiuting Wei and Wenbo Ning! UF Chemistry

Very happy to share the final chapter of my postdoc time in the Abe group 東京大学 | UTokyo . Wondering how a PLP-dependent enzyme utilizes NAD and SAM as substrates for a (3+2)cycloaddition to construct azaindane natural products? nature.com/articles/s4192…

Very excited to share that one of the major projects from my postdoc in the wonderful Piel Lab is out now Chem. An amazing collaboration with the Chekan Lab and Sanath Kandy where we characterized RiPPs with polycyclic isoprene moieties🎉 authors.elsevier.com/c/1jjdi8jWHELG…

A single diiron #enzyme catalyses the oxidative rearrangement of tryptophan to indole nitrile by Sanjoy Adak, Naike Ye, Calderone, Duan, Lubeck, Schäfer, April Lukowski, Ken Houk, Pandelia, @Drennan_Lab, & Bradley Moore MooreLabSIO in Nature Chemistry nature.com/articles/s4155…

Tired of low heterologous biosynthesis yields? Try GrowBio to rapidly make g/l bioproduction. Just give synthetic cells a reason to make your favorite compound like the octopus pigment xanthommatin. Led by Leah Bushin and out at biorxiv.org/content/10.110…

Happy to share our first independent work just out Angewandte Chemie: Natural methyl analogs of central sesquiterpenes widespread in actinobacteria! Exciting enzyme chemistry. Curious why they exist. A hidden "magic methyl effect" in the terpene world? onlinelibrary.wiley.com/doi/10.1002/an…