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Harnessing Diversity Generating Retroelements for in vivo targeted hyper-mutagenesis biorxiv.org/content/10.110… #biorxiv_synbio

Check out our new paper describing rAcrVIA1: an RNA anti-CRISPR that mimics guide RNAs to inhibit Cas13. Very fun project with stellar UW undergrad Victoria Hayes and collaboration with Ning Jia's group! science.org/doi/10.1126/sc…

Hello Seoul! Excited to be at #RECOMB2025! If you're curious about alternative protein tokenization methods for protein language models, swing by poster #100. Would love to chat—see you there!

Excited to share our last collab paper, now out in print Science Magazine!🎉 We reveal how dITP synthesis activates a SIR2 NADase effector to block phage infection! 🛡️🧬 science.org/doi/10.1126/sc…

Congratulations to Rotem Sorek (Sorek Lab) on your election to the US National Academy of Sciences as an International Member!!

Excited to share our latest on the Type II Thoeris system! In collaboration with the Sorek and Kranzusch labs, we identify His-ADPR as a signaling molecule. Huge thanks to all involved—amazing teamwork! nature.com/articles/s4158…

We performed a dedicated search of anti-CRISPR proteins targeting the model E. coli Type IE CRISPR-Cas system and revealed AcrIE9 as a potent inhibitor and the most widespread anti-CRISPR protein in enteric bacteria. biorxiv.org/content/10.110…

Our latest story is now online nature! We discovered a phage defense system that deploys kilobase-long DNA homopolymers to protect against viral infection. Congratulations to all authors, and to the Wiedenheft Lab for a fun and fruitful collaboration! nature.com/articles/s4158…

New pre-print(s) from the Sternberg Lab in collaboration with Leifu Chang! We uncover an unprecedented molecular mechanism of CRISPR-Cas12f-like proteins, which drive RNA-guided transcription independently of canonical promoter motifs. Full story here: tinyurl.com/mr3fd493