🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

#Recherche | Identification d’une nouvelle maladie génétique prédisposant aux infections chez les patients atteints de protéinose alvéolaire pulmonaire. 🦠 Assistance Publique – Hôpitaux de Paris (AP-HP) Inserm Institut Imagine Des possibilités thérapeutiques ? ➡ swll.to/MlKhOre

Well, well - been a long time coming! First reported IL-27 receptor mutations identified in modulation of the response to EBV!!! nature.com/articles/s4158…

The authors describe the clinical features, cellular & molecular mechanisms underlying immune deficiency in 7 patients w/ biallelic germline variants in CD4. This reveals important roles for CD4 in host defense against a range of pathogens, especially HPV. hubs.la/Q02rkZK_0

Out in Cell today! We describe the first humans with inherited, complete FLT3L deficiency. Despite a lack of most dendritic cells, they reached adulthood. See the thread below for the main highlights of our paper. cell.com/cell/fulltext/…

1/ We’re very proud of our PhD grad Masato OGISHI! A superstar in the lab since 2018, he co-authored >20 papers, including 6 as first/co-first author (so far!). This speaks to the volume of his productivity but also his collaborative spirit and generosity in helping others.

Join us for the 14th Latin American and Caribbean Immunology Congress (#ALACI2024) in Buenos Aires, Nov 4-8, 2024! 🇦🇷⭐️ Network with top immunologists, explore Puerto Madero🏙️🍷, and visit Iguazu Falls & Perito Moreno Glacier🏔️! Abstracts due Aug. 18th: loom.ly/Cr2jvfw

#SARSCoV2 brainstem encephalitis in human inherited DBR1 deficiency. New study from Yi-Hao Chan (Yi-Hao Chan Lab), Vanja Lundberg, Jérémie Le Pen, Jiayi Yuan, @harschnitz, Rice Lab, Lorenz, Casanova Lab, Olov Ekwall, Shen-Ying Zhang and colleagues: hubs.la/Q02Hh90t0

🦟 5 cas d'infections à virus du Nil occidental ont désormais été rapportés dans le Var, et plus de 70 dans toute l'Europe (dont 8 décès). L'infection, par piqûre de moustique, est généralement asymptomatique mais elle peut provoquer de rares formes neurologiques graves. 1/3

Félicitations à Casanova Lab pour leur nouvel article dans @nature mettant en évidence la première déficience héréditaire complète en TNF à l’origine de la tuberculose chez l’Homme ! Pour en savoir plus 👉 nature.com/articles/s4158…

A new nature paper from Drs. Andrés Arias (@AriasAAS) and Anna-Lena Neehus (@ALNeehu) explores how two cousins with a #TNF deficiency experienced recurrent bouts of #tuberculosis, but are unaffected by other pathogens. 📎 go.nature.com/3ToPSlU 🗨️ bit.ly/4gi9p1g

Autoinflammation in patients with leukocytic CBL loss of heterozygosity is caused by constitutive ERK-mediated monocyte activation Journal of Clinical Investigation Casanova Lab Bustamante Jacinta Jonathan Bohlen jci.org/articles/view/…

Patients with inherited CBL mutation and somatic loss-of-heterozygosity are known to develop spontaneously resolving JMML and to suffer from autoinflammation, particularly vasculitis. The underlying cause of this remained unknown. 2/8

Why do some patients with a CBL genotype develop autoinflammatory disease?jci.org/articles/view/… Jonathan Bohlen Casanova Lab and team report on chronic monocyte activation through the ERK pathway as a major contributor in patients with CBL LOF variants.

We are delighted to announce that the 6th APSID Congress and 3rd National Congress of Inborn Errors of Immunity & National Forum on Pediatric Immunology Congress Date: 11–13 April 2025 in Beijing, China. For further details, please visit our website at apsid2025.tiemeeting.com/EN

This is great! NIAID News have launched a collection of public domain illustrations (currently 550 individual icons) bioart.niaid.nih.gov

Happy to contribute to the training of LASID junior. Contenta en contribuir con la formación de los jóvenes de LASID 😍😍😍

Online now: Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling dlvr.it/TGPjfQ

📢Join the Bukavu Scientific Days 🧬 📅Jan 8-9, 2025 🌍Genetic predisposition to infectious diseases 📍On-site in Bukavu & Paris or Zoom (register for link) Organizers: UOB-Université Officielle de Bukavu, Casanova Lab, @DMurhuLa142024 & Guillaume VOGT #Science #Health #Genetics #Disease #Infectious

The 2024 IUIS Inborn Errors of Immunity (IEI) Classification has arrived! Explore our latest insights now at iuis.org/committees/iei. Find the report under “Annual 2024 Report”!

Impaired CD4+ T cell–dependent IFN-γ immunity in humans with LY9 deficiency underlies tuberculosis Science Immunology Casanova Lab Masato OGISHI Stephanie_Boisson-Dupuis science.org/doi/10.1126/sc…