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SAVE THE DATE: June 11-16, 2024. 16th Int'l Conference on #Complement #Therapeutics. Loutraki, Ancient Corinth, Greece aegeanconferences.org/src/App/confer…

How can we condense the expanding universe of #complementbiology into the confines of a few pages? Here's our humble attempt. Grateful to John D. Lambris, Ph.D. & George Hajishengallis and to all colleagues whose transformative research has thrust this field forward! nature.com/articles/s4157…

Thrilled to present our manuscript out today in Cell. A tour-de-force on anaphylatoxin complement receptors - 9 (!!!) unique GPCR structures: C3aR/C5aR1, biased/partial/full agonist, Go/Gq, mouse/human. doi.org/10.1016/j.cell…

This is going to be game-changing. We have launched a multidisciplinary hiring initiative at K-State to recruit 12 new faculty in biomanufacturing, supporting biosciences, and enabling technologies. Join us! k-state.edu/biomanufacturi… #NextGen #KState #biomanufacturing

1/3 Excited to share our latest research by the talented Dr Xaria Li on cell-intrinsic C5a in pathogen sensing and fungal killing. Out now in PNAS PNASNews pnas.org/doi/10.1073/pn…

Finally, a note on peer review that is currently so criticized. This work shows why peer review works! The experiments suggested by the reviewers led to a profound revision of our initial model! Without the pressure of an honest and firm peer review we would have gotten it wrong.

Our latest paper reporting identification of a small-molecule inhibitor of #complement protease C1s and the classical pathway is out in the newest issue of The Journal of Immunology. Special thanks to the students and postdocs who contributed to this team-driven effort! doi.org/10.4049/jimmun…

The first Legacy award for Complement Research was awarded today to Piet Gros by the Complement Society International Complement Society at an online symposium in his honor. We celebrated his amazing contribution to the Structural Biology of Complement. Congratulations 🎊 Piet!

Former #JI_Editor Brian V Geisbrecht Lab K-State BMB: 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide as a new class of small-molecule #complement C1s inhibitor #ReadTheJI #immunology 👉 ow.ly/4GWV50QzEil

We participated in Atomwise #AIMS study published in Scientific Reports highlighting #AtomNet as a viable alternative to high-throughput screening! Read about the largest and most comprehensive virtual HTS campaign to date: atomwise.com/2024/04/02/pre… #drugdiscovery #AI #pharma #biotech

Congratulations to Nitin Mishra for a successful defense of his PhD dissertation research on #Staph protease inhibitors. K-State BMB

First description of the self-amplifying nature of the #complement alternative pathway. Muller-Eberhard & Gotze, J. Exp. Med. 1972

New work from our lab published in Journal of Biological Chemistry! 👇 S. aureus Eap is a polyvalent inhibitor of neutrophil serine proteases - Journal of Biological Chemistry jbc.org/article/S0021-… Kudos to Nitin Mishra , Carson Gido, and Tim Herdendorf for leading this effort! K-State BMB

Yesterday a Nobel prize was given for alpha fold. Alpha fold could not exist without the Protein Data Bank (PDB), a public database funded by US taxpayers. Every structural biologist in the world that deposited their structure to the PDB indirectly helped train alpha fold.

It's clear that many do not understand what NIH-funded research does to improve health. It's time to revive a study published 10 years ago that provides incredible information about this. link in the comment Every single new drug approved by the FDA from 2010–2016 was built on

Congratulations to Duan for a successful defense of his PhD dissertation research on mechanisms of #complement inhibition! K-State BMB

Zymogen activation is a ubiquitous strategy for regulating enzyme activity. In our Journal of Biological Chemistry paper led by Duan, we show that blocking this fundamental process is used to inhibit the first proteolytic event of the classical #complement pathway 👇 doi.org/10.1016/j.jbc.…

Program Available: 17th Int'l Conference on #ComplementTherapeutics from May 10-15, #Sissi #Crete #Greece aegeanconferences.org/src/App/pages/…

Congratulations to all the trainee awardees! Great Work! Great Science! 17th Int’l Conference on #Complement Therapeutics.