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It was an honor to be nominated by Peggy Goodell as a @tamesttx protege and an even bigger honor to be selected as the ‘Science’ finalist for our work Center for Cell and Gene Therapy . Texas has a rich history of supporting medicine, engineering, science, and technology. Let’s keep it up!

Congratulations, Dr. K. King Katherine King MDPhD, recipient of the 2025 SPR Award in Honor of E. Mead Johnson recognizing outstanding #pediatricResearch achievements! BCMHouston Texas Children's TCHResearchNews #pediatricsInfectiousDisease societyforpediatricresearch.org/2025-award-rec…

In a follow-up of a phase 1 trial of a first generation CAR-T cell therapy in patients with neuroblastoma, 1 patient has had a sustained clinical response for over 18 years without requiring any additional therapy Che-Hsing Kevin Li, MD, Center for Cell and Gene Therapy @bcmHouston nature.com/articles/s4159…

🧠🔬"Diverse roles for astrocytes in brain circuits in health and disease." Thank you Junsung Woo, Ph.D for sharing your work with us! Do you think astrocyte cells drive the healing process? #CancerResearch

🧬Cancer treatment study in Harris County aiming to bring more patients access to life-saving care! Martha Mims M.D. and Premal Lulla M.D. are working  to provide cellular immunotherapy trials at Ben Taub. 👏 click2houston.com/news/local/202…

Long-term #survival supports the potential benefit of #CARTcellTherapy to treat solid #tumors. #Cancer Nature Medicine BCMHouston Dan L Duncan Comprehensive Cancer Center Center for Cell and Gene Therapy blogs.bcm.edu/2025/02/27/fro…

In a follow-up of a phase 1 trial of a first generation CAR-T cell therapy in patients with neuroblastoma, 1 patient has had a sustained clinical response for over 18 years without requiring any additional therapy Che-Hsing Kevin Li, MD, Center for Cell and Gene Therapy @bcmHouston nature.com/articles/s4159…

🧬"Opposing Effects of Dnmt3a and Tet2 Clonal Hematopoiesis on Alzheimer's Disease Pathogenesis" Thank you Katie Matatall PhD for sharing your work with us! Why do Dnmt3a and Tet2mutant HSCs have an advantage under inflammatory conditions? 👩🏼‍🔬#CancerResearch

Improving CD5 CART in T-ALL! Max Mamonkin from Center for Cell and Gene Therapy explores strategies to enhance the clinical activity of CD5 CAR-T in T-ALL at #iwCART25. 🧬🔬 #TALL #CD5CART #Hematology

🧬🔬"Dynamic control of lineage identity to overcome CAR-driven T cell dysfunction". Thank you Nathan Singh MD for sharing your work with us!  What strategies do you use to overcome T cell dysfunction?🤔#CancerResearch

🔬"Approaches to target solid tumors and the tumor microenvironment with adoptive T cell therapies." Thank you Katie McKenna Ph.D. Katie McKenna, PhD for sharing your work with us! What approaches have you found effective in targeting solid tumors?📝

🧵1/ T cells have deservedly been in the🔦for #cancer #immunotherapy, but other engineered cell therapies are now📈. What mediates NK cell exhaustion remains an important unanswered❓. 📄Link: nature.com/articles/s4158… I’m so thrilled🥳to share our work out now🚨nature

🧵9/ We further show that: ✅ Effects were strongest💪🏽when both CAR and IL-15 signaling were active. ✅ Mutating⚡️CD3ζ ITAMs abrogated this effect. Therefore, CREM is a potent intracellular checkpoint that limits CAR-NK efficacy.

Congrats to our Director Katherine King on her Cell Stem Cell paper out today showing Tet2-mutant clonal hematopoiesis protects against Alzheimer’s disease. From the Labs at Baylor College of Medicine TCHResearchNews Center for Cell and Gene Therapy