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Making bone: a small molecule approach Stem cells are a promising therapeutic tool that can be used for regeneration of bone. One way to control the differentiation of stem cells to bone forming cells is through the use of small molecules, known as corticosteroids.#lifETIMETC24

Making bone: a small molecule approach Such corticosteroids are also used clinically in the treatments of osteosarcoma, a primary bone cancer. However, their use greatly increases the production of undesired cell types such as fat, muscle and cartilage. #lifETIMETC24

Making bone: a small molecule approach My project aims to improve the potency and specificity of these molecules through organic chemical synthesis to promote stem cell osteogenic differentiation and to improve on the treatment of osteosarcoma. #lifETIMECT24

Our next #lifETIMETC24 speaker is Narjes Meselmani from Ollscoil na Gaillimhe | University of Galway who will talk about her project: The design and development of an electrochemical device for the detection of soft tissue necrosis. Follow our lifETIME Twitter Conference 2024 via #lifETIMETC24

1/3 Up to 7.7% of head & neck free flap surgeries suffer from perfusion issues, increasing patient morbidity & costs. Timely perfusion monitoring is vital to prevent ischemia & necrosis, but current methods lack real-time monitoring, risking flap salvage. #lifETIMETC24

2/3 Electrochemical impedance Spectroscopy offers a promising solution for real-time, continuous monitoring of flap perfusion. EIS detects changes in tissue perfusion by measuring electrical properties, allowing early ischemia detection for timely intervention. #lifETIMETC24

3/3 My project, LifETIME-CDT, aims to develop a system using EIS and microneedle arrays to monitor real-time skin flap perfusion. This technology will be coupled with machine learning for early detection of complications, ultimately enhancing surgical outcomes.

Our final speaker of the day for our #lifETIMETC24 is Xally Montserrat Valencia Guerrero from University of Glasgow who will talk about her project: Designing Animal-Free Organoids Based on Engineered Vegetables and Protein Crystals [VegFold].

VegFold- In the finding of a suitable material for substituting the Extracellular Matrix (ECM) in #TissueEngineering (TE) approaches, acellular plant tissues have been proposed as biomaterial for scaffolds due to their resemblance to mammalian ECM. #lifETIMETC24

Plant- derived scaffolds are produced after the removal of plant cells from the cellulose matrix of plant tissues (decellularisation). Then, human mesenchymal stem cells (hMSCs) can be seeded there and, by the addition of growth factors, differentiate into a tissue. #lifETIMETC24

The engineered tissue then can be used as a model for research and be applied to drug screening and testing providing a human- derived tissue, hence being more reliable for data collection than the current animal tissues being used. #lifETIMETC24

Thank you to all of our #lifETIMETC24 speakers for giving such wonderful talks for this years lifETIME Twitter Conference. Thank you to everyone who tuned in to the talks and engaged with our speakers.

Welcome to TCES x CDTs Joint Conference 2024! We’re kicking things off with our first keynote speaker Catherine Berry Followed by a series of talks from multiple CDT students 🗣️ #TCESxCDTs

Some of our lifETIME CDT Students had a great time attending #TERMIS2024 this week 🤩

📢📢We have a new 3 year studentship available at University of Glasgow! 👩‍🔬👨‍🔬 Deadline 04/09/2024 Please apply here: lifetime-cdt.org/apply/making-a… Project info here:lifetime-cdt.org/project-page/ #PhDposition #phdproject #PhDOpportunity #PhDProgram

Exciting PhD opportunity with LifETIME-CDT and Hannah Donnelly at the University of Glasgow To apply, please visit lifetime-cdt.org/apply/ #PhDOpportunity #LeukaemiaResearch #Bioengineering #StemCellResearch #DrugDevelopment #MedicalResearch #FullyFundedPhD

Reminder: 3-Year PhD Studentship Deadline Approaching! Application Deadline: September 4th Fully Funded with fees & stipends covered! Apply @ lifetime-cdt.org #PhDOpportunity #LeukaemiaResearch #Bioengineering #StemCells #MedicalResearch #FullyFundedPhD #lifETIMECDT

🆓 Free Patient Event! Living with or caring for someone with diabetes, epilepsy, heart disease, cancer or other chronic conditions? Come share your story and hear from experts! 📅 Date: 11.02.2025  |📍Location: Birmingham #Healthcare #PatientSupport #FreeEvent #MedicalResearch

Our innovative new Partnership PhD Programme has just launched! This programme offers industry employees the opportunity to undertake a PhD co-developed with UofG SciEng academics and aligned with the research needs of the company. Full details: gla.ac.uk/colleges/scien…

Read our latest blog by Dora Rogkoti from University of Glasgow who talks about her placement in Belgium: lifetime-cdt.org/2025/04/03/dor…