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Now online in Cancer Discovery: Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes - by Carlota Arenillas, ToledoLab_VHIO, and colleagues doi.org/10.1158/2159-8… Vall d’Hebron Institute of Oncology (VHIO)

Editorial: Cancer Discovery's Editors-in-Chief Dr. Luis A. Diaz and Dr. Lewis C. Cantley share their thoughts on "Connections across the Cancer Continuum" brnw.ch/21wRSX8

Now online in Cancer Discovery: Antitumor Activity of Vebreltinib & Characterization of Clinicogenomic Features in Tumors with MET Rearrangements - by Seshiru Nakazawa, Federica Pecci, Igor Odintsov, Pasi Janne, Mark Awad, et al. doi.org/10.1158/2159-8… Dana-Farber Memorial Sloan Kettering Cancer Center

From the April issue: Bone-Induced HER2 Promotes Secondary Metastasis in HR+/HER2- Breast Cancer brnw.ch/21wRUpN By Rahat Alam, Anna Reva, Igor Bado and colleagues Icahn School of Medicine at Mount Sinai The Tisch Cancer Institute

Attending #AACR25? Cancer Research Editor-in-Chief Christine Iacobuzio-Donahue and Cancer Discovery Editor Christine Lovly will moderate an interactive Professional Advancement Session on Monday, April 28. Register: surveymonkey.com/r/2025PubsPAS Chris Iacobuzio Christine Lovly, MD, PhD, FASCO AACR

News: Polygenic Risk Score Better than PSA brnw.ch/21wRW0D

News: Bevacizumab Biosimilar Approved brnw.ch/21wRW34

In the Spotlight: Do Not Lose Your Nerve: Adrenergic Signaling and Bone Marrow Regeneration after Transplantation brnw.ch/21wRW7d By Ravi Bhatia UAB UAB Medicine

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News: Novartis to Invest $23 Billion in U.S. Facilities brnw.ch/21wRZ5F

From the April issue: The FBXO45-GEF-H1 Axis Controls Germinal Center Formation and B-Cell Lymphomagenesis brnw.ch/21wS0Ai By Anagh Sahasrabuddhe, Xiaofei Chen, Kaiyu Ma, Megan Lim, Kojo Elenitoba-Johnson, and colleagues Memorial Sloan Kettering Cancer Center

Stay up to date by signing up for Cancer Discovery News Alerts: aacrjournals.org/pages/alerts?s…

Q&A: Lillian Siu and Matthew Vander Heiden Share Insights from the Forefront brnw.ch/21wS13f

News: Bispecific Bridge Helps NK Cells Target Lymphoma brnw.ch/21wS17t

Now online in Cancer Discovery: Precancerous Cells Initiate #Glioblastoma Evolution and Contribute to Intratumoral Heterogeneity - by Hyun Jung Kim, Jeong Ho Lee, and colleagues doi.org/10.1158/2159-8… #KAIST

In the Spotlight: Loss of p53 Induces Tolerance to Viral Mimicry as a Mechanism of Immune Evasion in Early Tumorigenesis brnw.ch/21wS24W By Takahiko Murayama and Israel Cañadas #CañadasLab Fox Chase Cancer Center @CEI-FCCC

Attending the AACR Annual Meeting? Register for “Productive Peer Review: Improving Science while Avoiding Pitfalls” on 4/28. Drs. Iacobuzio-Donahue & Lovly will moderate the interactive Professional Advancement Session. surveymonkey.com/r/2025PubsPAS Chris Iacobuzio Christine Lovly, MD, PhD, FASCO #AACR25

News: Cancer Throughlines: Almost 20 Years On, HPV Vaccine Still Surpasses Expectations brnw.ch/21wS3K4

News: NIH Could See Funding Slashed by 40% brnw.ch/21wS5fj

In Focus: Tackling Cancer through Global Team Science brnw.ch/21wS5fm By Rebecca Eccles, Gabriela Carreno, Lorenzo de la Rica (he/him), Gemma Balmer-Kemp, and David Scott Cancer Grand Challenges Cancer Research UK National Cancer Institute #CancerGrandChallenges