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We are excited to share our latest preprint! We systemically phenotyped, genotyped, and sequenced the Mass General Brigham Biobank (MGBB), including 150K participants with 53K genetic data. medrxiv.org/content/10.110… [preprint] (1/11) Broad Institute CGM at MGH MGH Cardiovascular Research Center Harvard Medical School

CGM Faculty Pradeep Natarajan talks with Eric Topol about preventing heart disease

New research from Austin Argentieri Mark Daly Aarno Palotie at CGM at MGH on #proteomic #aging published in Nature Medicine. The authors developed a proteomic age clock that is associated with nearly all major chronic diseases and mortality. nature.com/articles/s4159…

Trust in Physicians and Hospitals During the COVID-19 Pandemic in a 50-State Survey of US Adults in JAMA Network by CGM faulty Roy Perlis and colleagues shows decline. Read the paper loom.ly/0g-ffM8

CGM Faculty @heidirehm and colleagues in the GREGoR Consortium consortium recently published a manuscript encouraging and providing guidance for clinical labs to begin reporting novel candidate genes during diagnostic genome and exome sequencing.

New paper out by CGM faculty #JeremiahScharf with #DongmeiYu finds utilization of extensive hospital databases could improve the understanding of underdiagnosed illnesses, such as tic disorders. loom.ly/p0K_gqU @MGH_RI

The deadline to apply for a full time faculty position in Neurogenetics at the CGM at MGH and MGH Neurology is October 15th! Send your application in to be considered.

Congratulations to @cgm_mgh faculty Roy Perlis for his appointment as Editor in Chief of JAMA+ AI !

Glad to share pub Nature Genetics, shared first auth Alicia Chagoya, Philip Schroeder, Ravi Mandla CGM at MGH Mass General Brigham Broad Institute and Jiang Li Geisinger Research, with senior co-authors Miriam Udler Aaron Leong Alisa Manning and Lin Mirshahi nature.com/articles/s4158… 👇

Investigators at CGM at MGH, Mass General Brigham, Broad Institute Alicia Chagoya Miriam Udler, Aaron Leong, Alisa Manning, and Josep M Mercader 🎗 identify rare variants with intermediate effect between common T2D and monogenic diabetes. Nature Genetics loom.ly/bxQKbhc

We are delighted to announce this year's call for applications for the NHGRI-funded MGB T32 Postdoctoral Training Program in Precision and Genomic Medicine buff.ly/414Xajk Please RT or share w/ those who may be interested.

CGM at MGH Asso Member Patrick Ellinor and team use snRNAseq to dissect the molecular basis of atrial fibrillation (AF) loom.ly/ATzQiXQ Mass General Heart Broad Institute Nature Communications

Recent study by Art Schuermans, Michael Honigberg, MD, MPP, and @cgm_MGH faculty Pradeep Natarajan finds that large-scale analysis of the circulating proteome identifies new biomarkers, suggests therapeutic targets, and improves risk prediction for common cardiac diseases. loom.ly/n6mMKYk

Researchers Talkowski Lab used long-read sequencing and the T2T reference to characterize previously intractable genome rearrangements (e.g. ring chroms, Robertsonian translocations), shining light on their formation and consequences. Paper in AJHG loom.ly/IM3blt8

Our paper led by J. Shin MGH Cardiology Fellows & Aeron Small Brigham & Women's CV Fellows evaluating the longitudinal penetrance of HCM alleles in the Mass General Brigham Biobank sciencedirect.com/science/articl… JACC Journals #JACCAdv

CGM at MGH faculty Chris Anderson and team found polygenic risk scores, combined w/ clinical predictors, can help identify patients most likely to develop atrial fibrillation after stroke @MGH_RI Stroke AHA/ASA loom.ly/QQQFp8s

New paper in Circulation: Genomic and Precision Medicine: Traditional models assume genetic risk is constant, but Pradeep Natarajan & team including Sarah Urbut show CAD risk is dynamic. Genomic & clinical factors interact differently across life stages. @cgm_mgh MGH Cardiovascular Research Center @mghcvfellows loom.ly/D6zv7IM

So fantastic that NPR featured the unexplained troublingly high rates of heart disease among S Asian individuals, and our research efforts OurHealth to address these issues! npr.org/2025/02/11/nx-…

Read about a new study published by CGM Associate Member #NinaGold and team.

We are so excited to have you join us Alice Stanton !