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The next time you feel guilty of not having had a productive day, know that you produced almost a 100 kg of ATP #kickinggoals bionumbers.hms.harvard.edu/bionumber.aspx…

The structure and oxidation of the eye lens chaperone αA-crystallin nature.com/articles/s4159…

SMG1 is a giant #kinase of the PIKK family & required for #mRNA surveillance. This #cryoEM structure of human SMG1 reveals an unexpected & functionally important ligand that is also conserved in #mTOR & possibly other PIKK family members. Read more ➡️ ow.ly/nWwu50xp4ge

The latest study of @CJOkaiser of the Weinkauf Lab TU München and BuchnerLab was just published in NatureStructMolBiol revealing new insights into the structure and Oxidation of αA-crystallin. Check it out! Congrats to @CJOkaiser and all co-authors. nature.com/articles/s4159…

TDP-43 Regulates Coupled Dendritic mRNA Transport-Translation Processes in Co-operation with FMRP and Staufen1: cell.com/cell-reports/f…

Structural Insights into the Human Pre-mRNA 3′-End Processing Machinery cell.com/molecular-cell…

Cryo-EM structure of a 40 kDa SAM-IV riboswitch RNA at 3.7 Å resolution nature.com/articles/s4146…

Quality control within cells involves a variety of self-regulating activities. This cover was illustrated by Nigel Sussman, art directed by @MarcyAtarod, and animated by Nirja Desai scim.ag/34M92qC @sciencemagazine #ScienceVisuals

Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein: cell.com/neuron/fulltex…

It‘s out on biorxiv! Thanks to Oda H Schiøtz, Sven Klumpe, @ Matthias Pöge, @jon___schneider Florian Beck and Christopher Thompson for the productive work! Amazing colleagues, and Juergen M. Plitzko steadily supporting and enabling it all! biorxiv.org/content/10.110…

Glad to finally share our manuscript on “Serial Lift-Out” by the amazing twitterless Oda Schiøtz, Jürgen Plitzko, Christoph Kaiser , and myself. Doing multiple sections from single lift outs showing beautiful C. elegans ultrastructure 🤯 I could watch it all day 🤩How did we get there?

This enabled us to extract HUGE chunks and obtain tons of lamellae from them. It revealed all the beautiful anatomy that the C. elegans L1 larva has to offer. We are only highlighting a few here: nerve ring, pharny, body wall muscle, hypodermis and many more!

We anticipate the method to enable the study of multicellular organisms and tissues by cryo-electron tomography. To do the proof-of-princple, take a look at this nice ribosome at 6.9 Å!

Many Congratulations Sven Klumpe Christoph Kaiser and Microscopy & Spectroscopy colleagues. "Here, we introduce Serial Lift-Out, an enhanced lift-out technique that increases throughput and obtainable contextual information by preparing multiple sections from single transfers"

#EMPIAR10 celebrates 10 years of releases! Contribution by Rado Danev from the University of Tokyo. empiar.org #CryoEM #CryoET #VolumeEM #XRM #SBFSEM #FIBSEM #MicroED #DeepLearning #BigData #OpenScience

Out today from the Klumpe and Plitzko labs! Serial Lift-Out for greatly streamlined lift-out of lamellae for improved cryoET acquisition nature.com/articles/s4159…

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