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A review by eBIC staff on how #cryoET and computational techniques have been employed to study bacterial chemotaxis is now available! Find it here: doi.org/10.1042/BST202…

High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers | Nature Communications nature.com/articles/s4146…

Dr. Keith Cassidy C. Keith Cassidy is taking the stage! Exciting science talk on ‘Resolving new structural features of the E. coli chemotaxis core signaling unit’ combining molecular dynamics simulation, cryo-ET, AlphaFold2. #blastmeeting2023 @Blastmeeting

Martini model of an entire cell !!

Excited to share our most recent work on the giant ubiquitin ligase #BIRC6 out now in Science Magazine science.org/doi/10.1126/sc…!   Thread below 🧵 (1/7)

Keren (Keren Lasker) and I describe the science behind our recent Caulobacter illustration in "Integrative Visualization of the Molecular Structure of a Cellular Microdomain", now online ahead of print at Protein Science: onlinelibrary.wiley.com/doi/full/10.10…

Making more progress on the T4 phage illustration. All the mRNA (viral and cellular) is in, added most of the cell wall, and just finished adding a bunch of chaperonins. Now I need to add lots and lots and lots of soluble molecules.

Having this work published is a symbol of perseverance. From getting married, taking a leave for health, and moving to a different country, this work was there the whole way through! Thank you Ariane Briegel C. Keith Cassidy Flory Davi Ortega journals.asm.org/doi/10.1128/mb…

Advertising an MRC-funded DTP PhD in my brand new lab at Bristol University, using molecular modelling (and some expts) to understand the role of the membrane on µ-opioid receptor activity. RTs welcome. gw4biomed.ac.uk/how-does-the-m…

My name is Alise Muok and I just published my first fiction book! Six Fantasy/SciFi/Horror tales with illustrations and music included. Curious? You can take a look here: barnesandnoble.com/w/books/114400…

CheA histidine kinase, the "brain" of bacterial chemosensory systems, is a five-domain protein, as seen in E. coli and B. subtilis. Well, more often than not, this is not true! biorxiv.org/content/10.110…

New preprint with ZackB on the structure of apoB100 from human LDL! Special thanks to Mizzou Physics and IT/RSS that were instrumental in getting my new lab up and running!

In our article published today nature , we report complete all-atom structural models of a fully packaged bacteriophage particle. Congratulations to Kush Coshic on his first publication! Many thanks to Chris Maffeo and David Winogradoff for pushing this 6-year project forward.

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

The first independent publication from the Berndsen lab Mizzou Biochemistry in collaboration with my colleague C. Keith Cassidy is now peer reviewed and online at nature !! rdcu.be/d3kfg Resolving a many decades-old challenge, we determined the complete structure of

Insights into how cholesterol-carrying low-density lipoproteins are structured, and how they interact with receptors to enter cells, could help to clarify the role of these particles in cardiovascular disease nature.com/articles/d4158…

Our ApoB paper is out in print today in nature and since we didn't get the cover I can share our (C. Keith Cassidy ) beautiful artwork from molgraphics.com that wasn't selected 😆 rdcu.be/eaGPH

April's Molecule of the Month: Apolipoprotein B-100 and LDL Receptor Insights into how LDL is removed from the bloodstream pdb101.rcsb.org/motm/304