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Glasgow Coma Score & pupil reactivity=crucial #TBI outcome determinants but timepoints frequently missing in real-world data Evaluation of methods for effective imputation by CENTER-TBI... ... the answer depends on the question! doi.org/10.1371/journa…

First ever prospective randomised controlled trial to assess feasibility and safety of a 'digital biomarker' for individualised care of #TBI patients on #ICU ➡️ both feasible and safe #COGITATE doi.org/10.1089/neu.20…

Reduced physiological cross-talk associated with mortality after #TBI Well done Giovanna, @BrainPhysics @DrSmielewski @erta_beqiri Pietro Lio' AriErcole and all CENTER-TBI collaborators doi.org/10.1007/s12028…

COGiTATE results presented at the #BNRG2021 by our team member @erta_beqiri Great meeting, fantastic talks! Inspiration for the future @BrainPhysics @icm_plus

Yes, and Cogitate study is one of the most read papers in 2021!!

Primary analysis of NIHR GHRG on Acquired Brain & Spine Injury (ABSI) Global Neurotrauma Outcomes Study #GNOS published tonight The Lancet Neurology. thelancet.com/journals/laneu… Phenomenal collaboration of clinicians from 57 countries 🌍. #WFNS2022 #globalneurosurgery #globalneurotrauma #TBI

Some 𝘷𝘦𝘳𝘺 important things to know about the challenges of large-scale observational data collection in #TBI from CENTER-TBI doi.org/10.1007/s12028…

#TraumaticBrainInjury research often dichotomises outcomes. Here's how to handle ordinal outcomes from @shubhayu_neuro including a #machinelearning approach using 𝙖𝙡𝙡 the CENTER-TBI features for best prediction doi.org/10.1371/journa…

Unsupervised clustering in CENTER-TBI finds 6 stable endotypes of #TBI in the #ICU ⚠️Systemic metabolic stress important differentiating patients as well as traditional GCS classification doi.org/10.1186/s13054… rdcu.be/cSxc0

Machine learning and novel algorithmic techniques show great potential, but need to be applied and interpreted correctly Right question+right data+right method doi.org/10.1038/s41591… Cambridge Centre for AI in Medicine

Precision medicine to improve outcome after traumatic brain injury: data-driven approaches to identify pathophysiological or pathobiological mechanisms to individualize treatments 🧠suggestions for #TBI phenotypes 🧠methodological considerations #FOAMcc 🔓 rdcu.be/dhtsr

Does what happens in #ICU stay in ICU after #TBI? Well done shubhayu bhattacharyay, phd for time-series #machinelearning model ingesting 𝑎𝑙𝑙 CENTER-TBI data with minimal pre-processing looking at contribution of clinical course events to outcome in npj Digital Medicine nature.com/articles/s4174…

A solution to the age-old problem of where to zero the transducer in neurocritical care... rdcu.be/dlTOs doi.org/10.1007/s12028…

ICP is strongly confounded by therapeutic intensity level (TIL) after #TBI. Measuring TIL crucial to understand severity Various TIL scores validated in CENTER-TBI doi.org/10.1089/neu.20… shubhayu bhattacharyay, phd nails TIL representing 'refractory' ICP: TILᵐᵉᵈ≥7.5

Traumatic brain injury #TBI phenotypes from CENTER-TBI #ICU data by probabilistic time-series clustering 𝗧𝗲𝗺𝗽𝗼𝗿𝗮𝗹 𝘃𝗮𝗿𝗶𝗮𝘁𝗶𝗼𝗻 of brain injury 𝗯𝗶𝗼𝗺𝗮𝗿𝗸𝗲𝗿𝘀 = missing link in describing the 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 course authors.elsevier.com/c/1i5LY5FFzKyQ… The Lancet Neurology

Wonderful news for a remarkable colleague, friend, and doctor.

The President’s Commendation for a sustained contribution to the College was presented to Dr Rana Hafiz Ur Rehman. Dr Ari Ercole gave the Macintosh Professor Lecture. Seen here with President Dr Claire Shannon and Prof Iain Moppett. Read more: ow.ly/NsKo50UeHFx