
Integrative Physiology of Aging Laboratory
@cuaginglab
The Integrative Physiology of Aging Laboratory at The University of Colorado Boulder. Directed by Dr. Douglas Seals.
ID: 1546166397184618496
https://sealslaboratory.com/ 10-07-2022 16:19:40
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Some of our staff and students tabling to recruit participants at the Rocky Mountain Geriatrics Conference today! CU Anschutz Medical Campus


The most recent preclinical paper from the lab, led by Ashley (Mary) Darrah, Abigail Longtine and Zachary S. Clayton, PhD - "The influence of a human macronutrient-matched diet on phenotypes in old mice" now published in Geroscience. link.springer.com/article/10.100…

This #JournalClub by CeAnn C. Udovich (CUBoulderIPHY) examines the work of Morales-Palomo et al. (2024) and exercising to improve metabolic syndrome✍️ 🔗 Read it here: buff.ly/4iwn6KY


📢Please share: My lab group is seeking a motivated graduate student to join our team in Fall of 2025. Come join us University of Iowa UIowa Health and Human Physiology (HHP) as we study mechanisms of microvascular dysfunction in humans! Interested candidates should reach out to me for more information.

We would like to CONGRATULATE our 2nd place 2024 Best of Hypertension winners in the category of Basic Science: ahajrnls.org/3rNMBSM Vienna Brunt Abigail Longtine Ravinandan Zachary S. Clayton, PhD @CUaginglab


🚨 Join us for the EEP Trainee Workshop on crafting a research statement, teaching philosophy, and CV! 📍 Hilton Baltimore Inner Harbor - Key Ballroom 10 🗓️ April 26, 10:30 AM - 12 PM ✨ Panelists include: 🔹 Zachary Clayton 🔹 Erica Wehrwein 🔹 Scott Davis 🔹 Jacqueline Limberg

According to a study from scientists CU Boulder 🦬 and published in the @AHA Circulation Research journal, being older when you finish menopause is linked to a lower risk for cardiovascular disease. Read more about their research here. msn.com/en-us/health/o…


Sanna Darvish, MS et al found that women who completed #menopause later (>55 yo) have preserved vascular endothelial function due to lower oxidative stress & a more favorable circulating #lipid metabolite profile. Learn more at ahajrnls.org/41E97MV Kevin O Murray, PhD


1/6 New Circulation Research podcast #DiscoverCircRes bit.ly/4kANl4h! St. Hilaire Lab chats with Sanna Darvish, MS and Matt Rossman about their study Preservation of Vascular Endothelial Function in Late-Onset Postmenopausal Women (bit.ly/41sN2Q2)! Kevin O Murray, PhD



Recent review article on all things cellular senescence, vascular dysfunction and senotherapeutics! a collaborative effort by lab members Sophia Mahoney, Zachary S. Clayton, PhD, and Matt Rossman. Published in The Journal of Cardiovascular Aging oaepublish.com/articles/jca.2…

The PCC is thrilled to be working with American Physiological Society to support Rachel Cottle and Dr. Kevin Murray, winners of the 2025 PCC-sponsored #Antidoping Predoctoral and Postdoctoral #Research Awards! They will be presenting their research at #APS2025 April 24-27th in Baltimore.


Sophia Mahoney defended her dissertation in March and was recently awarded second place at the Physiological Omics Trainee session for her presentation on fisetin supplementation and prevention of plasma-induced endothelial dysfunction with aging! American Physiological Society Physiological Genomics


Congrats to Kevin O Murray, PhD for winning the APS EEP Section Partnership for Clean Competition Anti-Doping Postdoctoral Research Award and a successful Sprint Talk! American Physiological Society


Thank you to the APS CV Section for the opportunity to be a finalist for the CV Outstanding Graduate Student Award and the stage to present our research American Physiological Society. This work could not have been done without the support of my mentors who say yes to my crazy ideas



Congrats to Sophia Mahoney and Zachary S. Clayton, PhD et al on their recent short communication published in Aging Cell. They identify the natural senolytic 25-hydroxycholesterol as a potential therapy to reduce aortic stiffening in old mice. onlinelibrary.wiley.com/doi/10.1111/ac…

New pub alert! Here we demonstrate efficacy of fisetin (a food-derived senolytic) for reducing frailty and improving grip strength in old mice by altering gene expression (p21 & cell senescence markers). Check it out! Zachary S. Clayton, PhD Aging Cell Integrative Physiology of Aging Laboratory onlinelibrary.wiley.com/doi/10.1111/ac…