Attention everyone "Save the Date" and register early for our 2023 BHF Research Accelerator Symposia - Wednesday 11th October @ College Court, Leicester British Heart Foundation University of Leicester

#EMBOpopgen is back for its sixth edition, in person 13 – 19 March 2023 in Procida, Italy! Registration deadline 3rd Jan 2023 - RT please! Enza Colonna Andrea Manica Flora Jay Kelley Harris AnnaSapfo Malaspinas Benjamin Peter Leo Speidel Lucy van Dorp meetings.embo.org/event/23-pop-g… #EMBOpopgen

My lab will open its doors this summer in the Department of MCDB (MCDB Michigan). I have openings at all scales (PhD, Postdoc, Tech). Please contact me via email if you’re interested. I could not imagine a better environment to charter new frontiers in cis-regulatory biology!

The paper I am sharing today is a thoughtful philosophical perspective from Silvia Domcke & Jay Shendure proposing a new organizational framework for single cell data, as an alternative to e.g Human Cell Atlas Compelling read for both lovers❤️ & skeptics🤔 of single cell genomics 🧵🧵

A 🧵 on some of my intuitions/priors about the genetics of complex and molecular traits in humans (i.e. what I think of as typical), largely motivated by GWAS/QTL studies over the past decade [citing papers with nice figures where possible]

Our latest pre-print on head and body lice! We find males DO NOT have silenced paternal chromosomes, weird for a 'Paternal Genome Elimination' species! The exception of the exception that broke the rule 😂 #PGE #Lice #Epigenetics #GenomicImprinting biorxiv.org/content/10.110…

Our genome bioinformatics course at EMBL-EBI Training is coming back with a revised programme - this year we go from short- to long-read sequencing! 20-24 Nov 2023, Hinxton, UK Deadline 7th August! Solomon Charles Kayesha Coley Raheleh Rahbari Sean Laidlaw Maxime Tarabichi ebi.ac.uk/training/event…

This #AHAJournals #ResearchLetter provides a new mechanistic insight into the association between the chromosome 11q22.3 genetic locus and coronary artery disease. Solomon Charles Shu Ye #CardioTwitter #CVD ahajrnls.org/47ZtV2m

An update on this now 33 year old paper is in academic.oup.com/ije/article/49…

Anshul has a great mini-thread here (read up) on why predicting expression from sequence is conceptually much more challenging than predicting chromatin activity. I want to piggy-back on this with some dots that have still not connected for me:

The choice of whether to use Seurat or Scanpy for single-cell RNA-seq analysis typically comes down to a preference of R vs. Python. But do they produce the same results? In biorxiv.org/content/10.110… w/ Joseph Rich et al. we take a close look. The results are 👀 1/🧵

Mendelian Randomisation (MR) is going to hell in a handcart, with an exponential weekly increase of papers with Mendelian Randomisation in the title, most of them nonsense. 25th April 4.30pm online or in person UCL I'll talk about what should be done forms.office.com/pages/response…

"caQTLs and haQTLs capture regulatory variations not associated with eQTLs and explain ∼49% of the functionally annotated GWAS loci" Been clear for a while that accessibility & histone marks provide more info for explaining & fine mapping GWAS loci than expression. 1/

Amen. When I interviewed at Bell Labs at the end of graduate school, I was asked to prepare a 45 min talk that took me 90 min to deliver -- thanks to all the interrupting questions and debate that ensued. It was fantastic! It meant that they cared, and they pushed me in

Apply for this course if you would like to understand more about the technology, analysis workflows and resources for next-generation sequencing data analysis: ebi.ac.uk/training/event… Applications close 22 July #genomics #bioinformatics

Application deadline for our EMBL-EBI Training sequencing course is 22nd July! It covers all qc and mapping steps, variant calling for short and structural variants, how to analyse both short and long read sequencing data, and the basics of how to build a pipeline. Spread the word!

Stellar team of organisers and trainers including Raheleh Rahbari Pille Hallast Kayesha Coley Sean Laidlaw Maxime Tarabichi Solomon Charles Vic Flores 🦊 and Erik Garrison for our closing keynote lecture!

Last few days to apply for this PhD. Please share with any good undergrad/masters students you may have :) September 2024 - May 2025 start date. #FindAPhD #PhD #FundedPhD #Epigenetics #Toxicology #EnvironmentalHealth #HumanHealth #Pollution #PFAS

I have been invited to share my findings on the "Transethnic Mendelian Randomisation of Haematological Traits and Type-2 Diabetes Mellitus" at the weekly MRC/UVRI and LSHTM Uganda Research Unit and IAVI . Join us for an enlightening session! #seminar #research #phd #uvri

Top 4 things to know about doing science: 1. You need to have someone you can talk to 2. One-on-one discussions are the best 3. Think about discussions as improvisations and use the ‘yes, and’ rule 4. Create a safe space so both of you feel open to saying seemingly silly things