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Another exciting milestone in the search for selective CDK degraders Dana-Farber Chemical Biology Program: M. Teng, PhD & colleagues in the Gray lab Harvard Medical School report the development of a #CDK2/5 dual degrader with antiproliferative activity in cyclin E1-overexpressing #cancers onlinelibrary.wiley.com/doi/pdf/10.100…

Koichi Kawakami, 川上浩一 Yes, feel free to use the PDF file of the updated version of this timeline, which you can download at the link here: x.com/davidrliu/stat…

A so-called Duchenne smile can light up a room, but social smiles do the work of daily life — and those are the ones we lose when our face masks are on. nyti.ms/2VbFv6W

Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes dlvr.it/RZF2l2

My favourite is: 'One mentally fatigued penguin was allowed to come to a halting stop in front of a park bench and say “I just need a minute” to no one in particular.' HAHA More Activities That Penguins Have Been Permitted During Lockdown newyorker.com/humor/daily-sh… via The New Yorker

So proud of my team for our ACS Central Science paper on the first small molecule #KRas #PROTAC! And a special shoutout to Cesar Deleon (Cesar Deleon) for the killer cover art. @mike_bond20 Ling Chu Dhanusha Nalawansha Ke Li rb.gy/qhcqm3

Targeted Degradation of Oncogenic KRASG12C by VHL-Recruiting PROTACs dlvr.it/RbJCRc

Hi all - this symposium on targeted protein degradation starts in about 1 hour. The event hashtag is #TPDSympo and you can see my slides with the full transcript of my talk here: zenodo.org/record/3946428…

A new paper from @georg_e_winter and Cris Mayor-Ruiz performed chemical profiling in hyponeddylated cells coupled with multi-omics target deconvolution to identify molecular glue degraders of cyclin K. nature.com/articles/s4158…

Maybe if I ask the pandemic for commitment it'll go away

📢 We're delighted to announce our intention for parkrun events to return in England by the end of October. Read more from parkrun CEO Nick Pearson 📝 👉 parkrun.me/43huz

Jennifer Doudna wins 2020 Nobel Prize in Chemistry! The groundbreaking power & versatility of CRISPR-Cas9 has opened up new & wide-ranging possibilities across biology, agriculture & medicine, including the treatment of thousands of intractable diseases. news.berkeley.edu/2020/10/07/jen…

Excited to post our latest bioRxiv by Charlotte Zammit, Cory Nadel, Ryan Potts and our group on a covalent destabilizing degrader of AR and AR-V7 in androgen-resistant prostate cancer cells! Great collaboration with Amgen 🧪🔬🧬. biorxiv.org/content/10.110…

Happy to present our latest paper with Ryan Potts & Amgen 🧪🔬🧬 in J. Am. Chem. Soc. by co-first authors Charlotte Zammit & Cory Nadel on the discovery of a direct-acting covalent destabilizing degrader of AR and the undruggable truncation variant of AR, AR-V7, in androgen-independent prostate