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ASCI member Shadmehr Demehri Shawn Demehri MassGeneral News in JCI insight: Colonic thymic stromal lymphopoietin promotes tolerance to commensal gut microbiome: buff.ly/3rovAOg #Gastroenterology #Immunology

Carcinogen-exposed cancer cells suppress tumor-associated macrophages to promote immunogenicity: buff.ly/3LYRLlt Mei HUANG Xia Yun Shawn Demehri #Oncology

ASCI. member Shadmehr Demehri Shawn Demehri MassGeneral News in Journal of Clinical Investigation: Carcinogen-exposed cancer cells suppress tumor-associated macrophages to promote immunogenicity: buff.ly/3LYRLlt #Oncology

Statin blocks (TLR)3/4-TBK1-IRF3 pathway activation linking environmental insults to interleukin-33 induction in epithelial cells, which drives cancer-prone chronic inflammation. #CancerPrevention #ChronicInflammation #PancreaticCancer #SkinCancer nature.com/articles/s4146…

In a new Nature Communications study, researchers from Mass General Cancer Center and colleagues found that statin may prevent cancer by blocking inflammatory proteins. Read more: massgeneral.org/news/press-rel… Shawn Demehri

A study led by #MassGeneral physician Shawn Demehri, MD, Shawn Demehri was covered by Harvard Gazette. The study found that statins may block a pathway that leads to the development of cancer from chronic inflammation. news.harvard.edu/gazette/story/…

Commensal papillomavirus marks the mutant cells in sun-damaged skin for destruction by virus-specific CD8+ T cells. Tremendous work by Dr. Heehwa Son Heehwa G. Son and Colleagues #virome #aging #cancerprevention Cancer Cell cell.com/cancer-cell/ab…

#MassGeneral physician Shawn Demehri, MD, PhD, Shawn Demehri spoke to Medical Xpress about a study he co-authored; "Commensal papillomavirus immunity preserves the homeostasis of highly mutated normal skin." medicalxpress.com/news/2024-12-q…

In a new Cancer Cell study, researchers from MGHDermatology and colleagues investigated how the interplay between immune cells and HPV keeps skin healthy. Read more: massgeneral.org/news/research-… doi.org/10.1016/j.ccel… Shawn Demehri

Topical immunotherapy activates CD4+ T helper 2 (Th2) immunity to eliminate precancerous skin lesions and prevent cancer. Fantastic work by Dr. Tomonori Oka Tomonori Oka and Colleagues #Immunoprevention #Th2Immunity #Cancerprevention Journal of Clinical Investigation jci.org/articles/view/…

In a new clinical trial, researchers from Shawn Demehri’s lab at Mass General Cancer Center and colleagues created a new topical immunotherapy for the second most common type of skin cancer, squamous cell carcinoma. Read more: massgeneralbrigham.org/en/about/newsr… doi.org/10.1172/JCI183…

A promising target for skin cancer prevention and treatment! ASCI member Shawn Demehri & team MassGeneral News show topical calcipotriol plus fluorouracil immunotherapy induces the Th2/IL-24 pathway to eliminate premalignant skin lesions: jci.org/articles/view/…

Wang, Xia et al. demonstrate the efficacy of topical calcipotriol for breast cancer therapy, which relies on inflammatory CD4+ Th2 cell-macrophage crosstalk to induce IL-24-mediated breast cancer suppression: insight.jci.org/articles/view/… Shawn Demehri MassGeneral News

#RESEARCHHIGHLIGHT Immunosuppression disrupts normal skin homeostasis, raising the risk of cancer development. Now, in Cancer Cell, Shawn Demehri find that commensal HPV maintains homeostasis in sun-damaged skin. Read the highlight here 👇 bit.ly/4jLOlC4

Cell of origin explains the low immunogenicity of basal cell carcinoma, which can be overcome to enable BCC immunotherapy. #skincancer #Immunotherapy #Cancerprevention cell.com/cell-reports/f…

In a new study, researchers from the Mass General Cancer Center and colleagues found that basal cell carcinoma’s low immunogenicity is associated with suppression of antigen presentation stemming from its cell of origin. The study was published in Cell Reports. Read more:

Hepatitis B virus does not cause liver inflammation or cancer on its own. Instead, its interplay with environmental carcinogens generates immune dysregulation in the liver that leads to cancer development. #cancerprevention #virus #chronicinflammation nature.com/articles/s4146…

In a new study, researchers from Mass General Cancer Center and colleagues identified ways to lower risk of liver cancer for people with HBV. The study was published in Nature Communications. Read more: massgeneralbrigham.org/en/about/newsr… nature.com/articles/s4146… Shawn Demehri