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Beautiful work from Elina Ikonen, Abdou Rachid Thiam, and colleagues in Developmental Cell showing that seipin facilitates triglyceride flow to lipid droplets and counteracts droplet ripening via ER contacts. cell.com/developmental-…

We're also recruiting postdocs! DM or email if you'd like to join us in using integrated structural biology approaches combining #CryoEM and #insitu #CryoET to study #membraneproteins and molecular machines in #malaria parasites! Check it out👇👉tinyurl.com/5n96rkfm #teamtomo

Excited to share that the first paper from the Isom lab is now available on Biorxiv! (biorxiv.org/content/10.110…). We have investigated YhdP at the molecular level to show that it forms an envelope-spanning bridge and that putative phospholipids are found inside this bridge!

Want to know what happens when mitochondria get stressed? Check our latest pre-print with Simone Mattei lab on how mitochondria tether hibernating ribosomes as an adaptive response to glucose depletion in yeast! biorxiv.org/content/10.110… #teamtomo #cryoEM #ribosomes #mitochondria

It is my pleasure to announce the EMBO course on “In situ structural biology by Cryo-FIB and Cryo-ET” taking place Max Planck Institute of Biochemistry (MPIB) from 8.-14. April 2024. If you are interested in learning about cryo-ET and cryo-FIB including lift-out, apply by December 8th! meetings.embo.org/event/24-in-si…

Excited to introduce our novel cholesterol biosensor "GRAM-W" Nature Communications. Successfully visualized cholesterol in live cells, including neurons. Congrats to Dylan Koh, Tomoki, Minyoung! Thanks to the Lim and Zhong labs LKCMedicine for collaborations. nature.com/articles/s4146…

Excited to see our GEMs-as-cryo-ET tags paper now out in its final form! Compared to preprint we did more extensive tests and analysis, hope people find it useful.

New work from the Reinisch lab at Yale Cell Biology with the help of Melia Lab and the Burke lab: Spartin-mediated lipid transfer facilitates lipid droplet turnover

Almost up and running!! Waiting for the co2 incubator to arrive for the stem cells🥸 ps: I’ve received some applications, and am still open to more. Especially so if you are a student in Tübingen, don’t hesitate to drop me an email okay! You do not need any neuro background😎

VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1 biorxiv.org/content/10.110…

SPACEtomo: It allows for completely automated cryoET on lamellae without human intervention. Currently covering Yeast features and soon including other organisms. It can already take maps of all your lamellae and detect ice and cracks on any organism. biorxiv.org/content/10.110…

The SUSTech Fellowship program sponsors PhD students from universities outside mainland China to visit SUSTech and conduct research for 12 or 24 months. Each fellow could receive a yearly stipend of RMB 200,000 yuan (pre-tax). #SUSTech mp.weixin.qq.com/s/gN_k2IyFZzEe…

Over 4 years in the making, I am excited to share our pre-print on the “In-cell structure and snapshots of copia retrotransposons in intact tissue by cryo-electron tomography”. We used cryo-ET to resolve the copia capsid structure to subnanometer resolution inside cells. A 🧵

Another work from us on iPSC-derived DA neurons, this time round we characterize the different populations of secretory vesicles in these neurons, particularly in the context of vMAT2+ and vGLUT2+ vesicles. biorxiv.org/content/10.110…

High-res In-situ Structures of Mammalian Respiratory Supercomplexes in Reaction within Native Mitochondria biorxiv.org/content/10.110… Check out my lab's first work on membrane proteins! Yes, we knew nothing about detergent😜, so we directly imaged proteins within native membrane!

My new paper is now on BioRxiv 🎉🎉🎉🎉 twittorial to come 😊 Ectopic Reconstitution of a Spine-Apparatus Like Structure Provides Insight into Mechanisms Underlying Its Formation biorxiv.org/content/10.110…

Our work on cilia in dopaminergic neurons is well, finally out 😍pnas.org/doi/10.1073/pn…, stay tune for a follow-up preprint on ciliary calcium and pacemaking soon :)

🧠Janelia scientists have reached another milestone in connectomics: A wiring diagram of the fruit fly visual system. With 50K+ neurons, the optic lobe connectome provides the fullest picture yet of one of the most important parts of the nervous system. janelia.org/news/seeing-is…

Glad to contribute to this interesting story. I think everyone working on cryo-ET used to find this kind of interesting cage structures on the membrane. In this work, we identified one of them, and found a function of them. Stay tuned, more to come.😉

Excited to share our work published in NCB! We uncovered how plasma membrane curvatures spatially modulate ER-plasma membrane contacts, shedding light on the enrichment of these contacts at T-tubules in cardiomyocytes.Thank you to all our collaborators and everyone in the CuiLab!