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Super thrilled to share our new publication led by Ben Adler “Multicopy suppressor screens reveal convergent evolution of single-gene lysis proteins” on single strand RNA Fiersviridae #phages nature.com/articles/s4158…

If like me you like to analyse genomics data in Jupyter notebooks I have something for you: dbikard.github.io/genomenotebook/

BIG Congratulations to Nicole Marino who just signed her offer letter at UPenn @PennVet Pathobiology Departmant to start her own lab! The Marino lab opens Jan 1, 2024 focusing on new discoveries at the interface of phage and host immunity! s/o to Chair Igor Brodsky

It's finally out! 🚀 Before doing a genome-wide screen in P. aeruginosa looking for immune systems, look in these two conserved anti-phage hotspots we named cDHS1 and cDHS2. academic.oup.com/nar/advance-ar… Congrats to all the coauthors! Joe Bondy-Denomy Erin Huiting Alan R Davidson

The increasing discovery of anti-phage bacterial immune systems (>100 in 5 years!) means an increasing diversity of phage activators. Here, Joe Bondy-Denomy and I review phage proteins as a prominent ‘pattern of pathogenesis’ and how they activate immunity. tinyurl.com/tmrpwrnk

no one: scientist: you guys i did some great science! i'm so excited! scientist: I'm going to print it on an ENORMOUS sheet of paper scientist: like really big. QUITE BIG scientist: and then take it on a plane and go somewhere and show it to people

Class picture time for incoming Rockefeller University grad student class!

Happy to share our new preprint! We used viperins🐍, to understand the conservation and diversification of immune genes across domains of life. A deep dive in the evolutionary history of immune genes shared by prokaryotes and eukaryotes! biorxiv.org/cgi/content/sh…

I’m really excited to share our new pre-print “Genome-wide Characterization of Diverse Bacteriophages Enabled by RNA-Binding CRISPRi”, with co-first author Muntathar Al-Shimary @doudna_lab and the newly-minted Brady Cress lab! biorxiv.org/content/10.110… 🧵🧵 1/

Yesterday, i had the honor of becoming part of the first Scientific Council for the French President, among a group of 12 incredible scientists. A tad far from my 🦠, but hopefully will help a bit in fostering the role of science & knowledge in our society and democracy.

Hachiman is hot off the (preprint) presses! Owen Tuck and I in @doudna_lab present a model for how this broad-activity defense system recognizes genome integrity, a core feature of phage infection. Check out the preprint and Owen's thread for the news:

New preprint from the lab, led by outstanding student Claire Kokontis! (Claire Kokontis) In this work Claire et al. discover Imp1-Imp6, phage proteins required for the selective import of proteins into the jumbo phage nucleus! Imp1 (below) is the special one. biorxiv.org/content/10.110…

Excited to share my latest work from the @MarraffiniLab, in collaboration with Phoebe Rice, now online nature!! nature.com/articles/s4158… We report the discovery of DNA glycosylases that provide anti-phage defense in bacteria! A thread 🧵: 1/

I am thrilled to start my lab as an assistant professor Biozentrum, University of Basel & NCCR AntiResist of University of Basel this fall. I will continue my research interest in bacteria & jumbophage interactions. Equally thrilled to be closer to our families after 10+ years.

Excited to introduce AntiDefenseFinder - a free, open source tool that detects anti-defense systems in any genomic sequence. Available here to toggle on/off: defensefinder.mdmlab.fr. Read below for our insights into the >47K detectable systems📈 tiny.cc/8xrizz

Did you know that bacteria remember their past for many generations? In this new preprint from us (Alexis Villani and Senen Mendoza) and Banin lab (Esther Shmidov ), we reveal the "how?" and "why?" underlying a long-standing mystery in bacterial memory. biorxiv.org/content/10.110…

phages are spooky

It is finally out! Muntathar Al-Shimary, Doudna Lab, Brady Cress and I present a gene knockdown tool that works in diverse phages: CRISPRi through antisense RNA Targeting (CRISPRi-ART)! Check out the final paper in Nature Microbiology nature.com/articles/s4156…

Grad student Héloïse Carion of the Marraffini lab was interviewed by Molecular Cell about her latest paper on the activation of bacterial programmed cell death by phage inhibitors of host immunity. Check it out here: cell.com/molecular-cell…