🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

all good DDx! this was perhaps indeed #TooCloseToDiagnose but Samson W. Fine, MD was closest this was hemangioma-like foci in a low grade clear cell RCC (lower power you can👁️more solid tumor cell aggregates) ✔️paired CA9 #IHCpath (note just how many sneaky tumor cells there are!)

Enjoy short YouTube video and summary points of recent white paper published in European Urology and AJSP from 2 leading uropathology societies: GUPS and ISUP. It was an honor to co-lead on this important healthcare project. youtu.be/W-n5yoip-pI?si…

#GUpath bladder lovers: take a read at this fantastic editorial by Drs. Sara Wobker & Steven Smith in the upcoming AJCP issue: Urothelial carcinoma-are we moving beyond "divergent differentiation" and "histologic subtype"? pubmed.ncbi.nlm.nih.gov/40512055/

thanks also for highlighting our recent study led by Carol N. Rizkalla, MD on Urothelial carcinoma with osteoclast-like giant cells: An expanded immunohistochemical and molecular profile pubmed.ncbi.nlm.nih.gov/40512053/

too easy for you! indeed, these are just mast cells (tumor cells neg; I'll tell you that re-review of this outside case, this CD117 was interpreted as "patchy positive") just a pinkish clear cell RCC (diffuse/complete CA9 and neg CK7)

Osteoclastic-rich urothelial carcinoma is currently categorised under poorly differentiated urothelial carcinoma, but we think it warrants being classified as a unique UC ✨subtype✨! We look into morph, IHC, and molecular features - What do you think? #GUPath #PathTwitter

admittedly hard off 1 image...but if PIN4 had been done I suspect % at "atypia/ASAP" might have been even higher (basal markers would be NEG btw, and no AMACR) Dx: just vacuolated change in a vessel (see more pics/levels here) #beautyinb9 but Huge Jass 🔬potential pitfall!

Lymph nodes pitfall 🛑 Intraparenchymal nevus cell aggregates in lymph nodes-possible pitfall with carcinoma/melanoma Good news: According to studies (see second pic) intraparenchymal nevi always occur with capsular nevus component They are morphologically different from primary

Urothelial carcinoma - biomarkers: MMR: do on all upper tract UC HER2: do, ideally upon request, preferably on metastatic lesions. Use gastric HER2 scoring (DESTINY-PanTumor02 trial) Dr. Al-Ahmadie #USCPAP25 #pathology #PathX

HER2 IHC scoring- Pan HER2-Dr. Troxell -Breast: Breast HER2 scoring -All other organs: Gastric HER2 scoring Exception to this is Endometrium (USC): Use both endometrium HER2 scoring (Dr. Buza/Fader scoring) and gastric HER2 scoring No need for reflex HER2 FISH (when having HER2

Picture 📸 perfect radial scar #breastpath. ➡️ Central fibroelastotic core ➡️ Star-like radiating ducts and lobules that may contain atypical proliferations (hyperplasia, DCIS) ➡️ Good mimicker of carcinoma of imaging 🩻 and on gross 🔪 ➡️ Variable tx, sometimes excision

Endometrial carcinoma-Molecular classification NSMP (non-specific molecular profile) EC group can be separated in two -Low grade ER positive -High grade ER negative Low-grade and ER-positive NSMP ECs are a homogeneous low-risk group associated with an exceptionally favorable

Proposed decision algorithm for diagnosis of uterine smooth muscle neoplasms with atypical features 94% of LMS showed ≥ 1 genomic alteration involving TP53, RB1, ATRX, PTEN, CDKN2A, or MDM2, with 80% showing alterations in ≥ 2 of these genes. Two or more abnormal IHC results

Excited to share our review on renal tumors with defined molecular alterations! journals.sagepub.com/doi/full/10.32…

Reppin’ pathology on a TikTok trend 💥 Went viral proving we’re not just “quirky awkward basement dwellers”—we’re brilliant, essential, and the backbone of medicine. #PathTikTok #PathX #matchtopath

Daniel Berney Michelle_Hirsch (Donovan) Diagnosis of CIS in fragmented TURBT specimens is often difficult and subjective. Only CIS away from papillary tumour should warrant categorisation as very high risk (potential upfront cystectomy). Have a high threshold for diagnosing CIS in TURBT specimens.