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7 years ago, I met a junior fellow named Jason Buenrostro who blew me away with a vision of futuristic genomic technologies Today, we (Ajay Labade, @carolinecomenho) are excited to share our first steps into that future: Expansion in situ genome sequencing 1/

So excited to finally share ExIGS, a new tech we (zack chiang Ajay Labade Jason Buenrostro) developed to combine spatial genomics with expansion microscopy

Stoked to see expansion in situ genome sequencing (ExIGS) through hard work by zack chiang, Ajay Labade, @carolinecomenho! Early proof of concept was a big part of my PhD with Andrew Payne and zack chiang. Amazed by the robust protocol and amazing data the new team developed.

Thrilled to see our ExIGS tool featured! A true testament to the power of collaboration. Huge congrats to the team for their hard work! 🧬Ajay Labade zack chiang Caroline Comenho nature.com/articles/d4158…

A new combination technique enables DNA sequencing and high-resolution imaging in intact cells — offering new insights into progeria and aging. broad.io/expansion-in-s… Jason Buenrostro Fei Chen Lab Ajay Labade Caroline Comenho zack chiang Science Magazine

Super excited that Expansion In Situ Genome Sequencing (ExIGS) is out now in Science Magazine ! Check out the paper to see what can be revealed by sequencing the genome in its native position and high-res imaging its interactions with nearby proteins. science.org/doi/10.1126/sc…