🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

We tried to solubilize the claudin, rhomboid, and GPCR membrane folds. Using vanilla ProteinMPNN, we were not able to design soluble versions of these proteins, so Justas Dauparas trained a new version called SolubleMPNN resulted in many soluble designs of these folds.

Lastly, confirmed that the soluble analogues maintain the intricate topology of the membrane folds using crystal structures. This allowed us to further explore the sequence space of membrane topologies and achieve a de facto fold expansion of the soluble space.

@ramithuh Casper Goverde Zhidian Zhang Juan José Pierella Turns out Tom Hanks was in town, but, unfortunately, was a bit out of reach.... so Casper Goverde, with the magic of Adobe Photoshop and a little generative ai, made the dream come true 😶‍🌫️

⚛️Protein structures are key to elucidating molecular details of cellular processes. #AlphaFold2 & others unveiled millions of tertiary structures, but these proteins' quaternary structures remain mostly a mystery. Here's how to bridge the gap. Thread👇 biorxiv.org/content/10.110…

New amazing research from the Bruno Correia lab! Zander Bühler Harteveld and Alexandra explore protein topologies that have not been found in nature using a novel deep learning pipeline called Genesis

So happy to see our work published at Cell ! We added the quaternary structure dimension to proteome-wide, #AlphaFold2 predictions: The published paper: sciencedirect.com/science/articl… The original 🧵 (Two more experimental structures since!) x.com/ElevyLab/statu…

Incredible work by the Levy lab! Using AlphaFold2 to generate a database of the multimeric proteome. This collaboration easily ranks among my top favorites 😍 Happy to share our joint effort with the world 🌟

THEY SAID WE COULDN'T DO IT........well, no one actually said that. But in our updated manuscript with Casper Goverde, Nico Goldbach, and Bruno Correia we show you can now design soluble analogues of membrane proteins with preserved functional features! biorxiv.org/content/10.110…

New preprint! In this project spearheaded by Anthony Marchand and Stephen Buckley we designed new chemically-induced protein interactions and experimentally validated three binders targeting Bcl2:Venetoclax, DB3:Progesterone and PDF1:Actinonin complexes. biorxiv.org/content/10.110…

Our method for molecular linker design with diffusion models (DiffLinker) got published in Nature Machine Intelligence 🥳 nature.com/articles/s4225… Thanks a lot to our amazing coauthors Hannes Stärk Clément Vignac Arne Schneuing Víctor Garcia Satorras Pascal Frossard Max Welling Michael Bronstein Bruno Correia

Today in nature we present the results of our exploration of the soluble protein universe and the design of functional soluble membrane proteins with Casper Goverde Nico Goldbach Bruno Correia 1/6 nature.com/articles/s4158…

The last two years of my PhD I've worked with great pleasure with Martin Pacesa Nico Goldbach Bruno Correia and many others. When we started this journey we had no idea where this project would lead us, so I feel deeply humbled that we managed to publish our work in Nature.

Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. Bruno Correia Sergey Ovchinnikov biorxiv.org/content/10.110…