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📢 Very 🔥 out of press! Our paper about #metabolic reprogramming in DC during development and activation. OPEN ! (enjoy) nature.com/articles/s4146… #natcomms DC can 🔥 or🧯adaptive immune responses (IR). Also Metabolism can 🔥 or🧯 IR. Little "zoom" on this story:👇 🧵

How we think and talk about mitochondria matters to our science and to newcomers in the field. The powerhouse analogy is expired and we need specific vocabulary to capture the beautiful complexity of mitochondrial biology. We propose a framework and some nomenclature.

Imagine working for the University of Pennsylvania's marketing department: "Penn: We gave diplomas to Donald Trump and Elon Musk but denied tenure for a woman who won the Nobel Prize in Medicine"

A negative Covid antigen test is less reliable these days. In this study, symptomatic, PCR+ people didn’t reliably test positive by antigen test until the 3rd, 4th, or even 5th day of symptoms. Sensitivity Day 1: 30%-60% Day 3: 60%-75% Days 1-7: 60%-80% academic.oup.com/cid/advance-ar…

Our paper debunking the 2020 cancer microbiome results is now published, in mBio. We'll see if @nature (or the authors) will retract these deeply flawed results. h/t Professor Booty PhD Eric Topol journals.asm.org/doi/10.1128/mb…

ChatGPT use shows that the grant-application system is broken nature.com/articles/d4158…

I was teaching and someone asked me what they could tell their daughters to keep them safe from rape & sexual violence. They said they felt there must be some proven safety advice that actually works, to protect women and girls from being sexually abused or raped. And I said:

Good advice on navigating a career in academia “I realized that what needed to change was not my work, but my mindset. I had to learn to accept that perfection is an illusion and that there is a place for compromise”

Data published today Annals of Surgical Oncology showing improved survival for patients with advanced ovarian cancer. Thanks to all the team Mater Hospital Advanced Cancer Care MaterSurgery ThisisGO.ie for all the hard work and to all of the patients who entrust themselves to our care rdcu.be/dpoDV

Complete remission of ankylosing spondylitis (an autoimmune arthritis) in a patient following depletion of TCR Vb9+ T-cells. Very inspiring. nature.com/articles/s4159…

Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes nature nature.com/articles/s4158…

We have funding for a #postdoc on a super cool project imaging the human liver & furthering our understanding of tissue-resident #Tcells ... is anyone looking? Pls do get in touch 😃😃 We're a super friendly group, growing in size constantly & in the IIT in London!

Wonderful opportunity to join our stellar HPB & Transplant unit in Dublin St Vincent's University Hospital (SVUH) 🟢2 Yr Fully-Funded & Accredited Fellowship 🟢Significant Operative Experience 🟢Research Opportunities 🟢Just in time for #eahpba2025 Dublin! SVUH Surgery E-AHPBA IHPBA svhg.recruitment.zellis.com/wrl/pages/vaca…

New The Lancet Respiratory Medicine Substantial (~40%) reduction of #LongCovid via Covid vaccines in 4 large multinational cohorts, and ~15% greater with mRNA than AZ vaccine thelancet.com/journals/lanre…

This is a project that I'm really excited to be working on. We're looking for one more person to join our lovely team - it might be you! 👀

RT's would be greatly appreciated. Thank you all for your support so far! 💜

Interrogating dynamics of fuel utilization by CD8 T cells in vivo reveals metabolic checkpoints for immune function in vivo Science Advances Russell Jones science.org/doi/10.1126/sc…

#TickTock 🕰️! Douglas, Lydia Lynch &co show nature that IL17 production, especially by gd T cells, follows a circadian rhythm impacting adipose tissue lipogenesis. Disruption of the clock or of the IL17 axis alters whole body metabolism & temperature! nature.com/articles/s4158…

The source of dietary fat influences anti-tumour immunity in obese mice go.nature.com/4o2w4CJ