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Charting the development and engineering of CRISPR base editors: lessons and inspirations dlvr.it/TLSlgx

EGR2 O-GlcNAcylation orchestrates the development of protumoral macrophages to limit CD8+ T cell antitumor responses dlvr.it/TLSpm5

Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation dlvr.it/TLSstW

Mechanism by which the molecular glue-like verteporfin induces IRE1α dimerization and activation to synergize with AKT inhibition in breast cancer dlvr.it/TLSx6C

A cationic amphiphilic drug synergizes with strobilurin fungicides to control fungal-borne plant diseases dlvr.it/TLSzyL

Electrochemical sensor toolkit for simultaneous glutamate detection at edge of cleft and peri-soma dlvr.it/TLT2dC

Online now! Site-resolved assessment of targeted protein degradation dlvr.it/TLn8Bk #chembiol

Online now! Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity dlvr.it/TLpFqX #chembiol

Online now! Covalent inhibition of ACSL4 alleviates ferroptosis-induced acute liver injury dlvr.it/TLqNRr #chembiol

Online now! A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner dlvr.it/TLvvTQ #chembiol

Attend the 2025 Bringing Chemistry to Medicine Symposium to learn from leading experts in transcription, chromatin regulation, computational biology and chemical biology. Registration is free and available both in-person and virtually.

The July issue of CellChemicalBiology is now live. Read the full issue here: dlvr.it/TLzFF8

RPL22 links ribosome biogenesis, RNA splicing, and sensitivity to RNA polymerase I inhibition dlvr.it/TLzt3P

Ribosomal RNA transcription regulates splicing through ribosomal protein RPL22 dlvr.it/TLzxPx

Powering the powerhouse: Mitochondrial NADPH propels oxidative metabolism dlvr.it/TM00Qw

Silencing stress: Structural insights into ISR termination by the SIFI ubiquitin ligase dlvr.it/TM03Rt

Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity dlvr.it/TM06dL

Covalent inhibition of ACSL4 alleviates ferroptosis-induced acute liver injury dlvr.it/TM09Nc

A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner dlvr.it/TM0ChJ

Site-resolved assessment of targeted protein degradation dlvr.it/TM0FmL