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New Preprint out from the Vecchiarelli (Anthony Vecchiarelli) and Biteen (Julie Biteen) Labs! "An experimental framework to assess biomolecular condensates in bacteria" biorxiv.org/content/10.110…

We made the cover of @CellSystems! Elementary landscapes for two fitness functions reveal that combining them creates a more rugged landscape. This highlights the demand on a DNA-binding domain to evolve affinity for distinct half-sites Colin Jackson tinyurl.com/yc2web9a

We have a new preprint on optical patterning of Nodal signaling in zebrafish embryos: using light to sculpt embryonic development! biorxiv.org/content/10.110… Beautiful work led by Nathan Lord and Harry McNamara

The regulatory capacity of dynamic systems is rich & fascinating. They can enable a common regulatory hub to differentially regulate diverse physiological processes. pubs.acs.org/doi/full/10.10…

Excited to present PHAGEPACK for quantifying genome-wide which bacterial host factors impact phage infectivity. PHAGEPACK combines CRISPRi with phage packaging. Reveals phage-host interactions, evolution, & host resistance. Great work by Chutikarn ! biorxiv.org/content/10.110…

Incredibly honored to be selected as one of the 2024 Schmidt Science Fellows! Excited to join the SSF community and collaborate with so many inspiring individuals. Looking forward to this journey ahead!

Congratulations to Assistant Professor Monica Neugebauer (Monica Elena Neugebauer), who is a 2024 recipient of the Shaw Early Career Research Award! The $200,000 award is sponsored by Greater Milwaukee Foundation. Learn more about Neugebauer's research: biochem.wisc.edu/2024/04/24/neu…

ASCB MEMBER NEWS Judith Kimble & Others Wins the 22nd Annual Wiley Prize in Biomedical Sciences Congrats to ASCB Member Judith Kimble & colleagues who won the 22nd annual Wiley Prize in Biomedical Sciences for their discovery of the stem cell niche. ow.ly/bhrX50Rpfhf

Imaging the entire course of tissue regeneration requires transparent animals, efficient transgenesis & microscopes that can image free-behaving animals. Here we present a toolkit and reveal dynamic cellular processes during regeneration of Macrostomum. biorxiv.org/content/10.110…

Happy to share that work led by grad students Zack Harmer and Jaron Thompson, with significant contributions from David Cole, is now out in the journal ACS Synthetic Bio. This work developed out of a productive collaboration with the research groups of Zavala and Venturelli.

Following our field's inspiring history of building synthetic receptors, here we share our lab's first attempt at a post-transcriptional one. Based on ADAR-editing and compatible with various inputs/outputs.

At #ASGCT2024, we're showcasing advances in non-viral gene editing, CAR T cell therapies, & high-throughput screening. Explore our work on vision restoration, cancer therapy, and ethical challenges in the field. Join us to learn about the latest progress in #GeneTherapy research

Our paper is finally out in it's final form!

Ingenious strategy to repurpose a bacterial E1-like enzyme to emulate ubiquitin-like cascades for ATP-driven protein ligation. Its like a battery pack for powering bioconjugation reactions 🔋!

Tenured. Thankful. Look out.

enjoy the awesome experience, science, and people Kyle Flickinger and Gina Wade! super proud of & very excited for you both! way to rep metabolism & interdisciplinary work UW-Madison IPiB UW–Madison Biochem Morgridge Institute cc: Judith Simcox PhD Rutter Lab Gregory Ducker

Also check out the great write-up by Eli Ramos and Taylor Kubota at Stanford Reports: news.stanford.edu/stories/2024/0…

Some say hybrid comp/expt labs, where dry lab meets wet lab, are "at the beach". Hbt "the shore of Lake Mendota" ? I'm thrilled to join Biochemistry at UW-Madison! Starting 2025, the Wayment-Steele lab will unite AI & experiment to transform how we study biomolecular dynamics.

Thrilled to share our collaborative study led by Brent Aulston and Kirstan Gimse, PhD in my lab! 👇This work is a pivotal proof-of-concept in mice showing that in vivo #CRISPR editing in the brain has potential to treat Alzheimer’s disease. 🌟🧠 @NIGMS Somatic Cell Genome Editing (SCGE) Outreach

Excited to share a new paper from the super creative and talented Eden! Eden engineered droplet-forming sequences to act as regulatable glues for stitching microtubules together inside living cells 🧫🧪