The fantastic rSAM spliceases paper is finally online. So happy to be part of the story. Congrats Piel Lab Tom Scott.

Join us for the last CFBD Seminar Series in 2023! Hear A/Prof Anders Bach from the @group_bach at University of Copenhagen Research. Register here: bit.ly/3UjzLnF EMCR_MIPS Monash Institute of Pharmaceutical Sciences GRIDD Kassiou Group Joel Mackay Prof Sally-Ann Poulsen🌻 ARC CCeMMP

Excited to share, along with brilliant collaborators, Squire J. Booker & Ed O'Brien Penn State Chemistry, our paper in Nature Chemistry explaining the biophysical basis of how synonymous codon mutations can alter protein structure and function. Short 🧵1/9. nature.com/articles/s4155…

Our recent work on Streamlined Chemoenzymatic Synthesis of Cyclic Peptides by Non-ribosomal Peptide Cyclases is out in J. Am. Chem. Soc. . Congrats for Masa and Kei! pubs.acs.org/doi/10.1021/ja…

In a collaboration between Buchwald Group & PenteluteLab, we developed peptide-encoded libraries (PELs) as a new platform for small molecule drug discovery. This work with @NathalieGrob is now out in Science Magazine science.org/doi/10.1126/sc… #ScienceResearch MIT Chemistry

I’m pleased to share our latest work on high-throughput thiol-ene chemistry, now published in Peptide Science (Open Access)! onlinelibrary.wiley.com/doi/10.1002/pe…

Peptide Selenocysteine Substitutions Reveal Direct Substrate–Enzyme Interactions at Auxiliary Clusters in Radical S-Adenosyl-l-methionine Maturases OHSU News Utah Chemistry Vahe Bandarian University of Utah #Peptide #Selenocysteine #Clusters #Radical #SAM #Maturases pubs.acs.org/doi/10.1021/ja…

please check out the natural product-inspired peptide macrocyclization method we developed, these reactions are fast and simple to perform Utah Chemistry University of Utah J. Am. Chem. Soc. pubs.acs.org/doi/full/10.10…

Discovery and #Biosynthesis of Cihunamides, Macrocyclic Antibacterial RiPPs by Joon Soo An, Hyunbin Lee, Hyungyu Kim, Seungyeon Woo, Hyunsung Nam, Jayho Lee, Ji Yun Lee, Sang-Jip Nam, Sang Kook Lee, Ki-Bong Oh, Seokhee Kim, Dong-Chan Oh in Angewandte Chemie onlinelibrary.wiley.com/doi/epdf/10.10…

Substrate-Controlled Catalysis in the Ether Cross-Link-Forming Radical SAM #Enzymes by Suze Ma, Wenhui Xi, Shu Wang, Heng Chen, Sijia Guo, Tianlu Mo, Wenxue Chen, Zixin Deng, Fener Chen, Wei Ding, and Qi Zhang in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

I'm pleased to share our latest review on cyclic peptide therapeutics. Now online in Angewandte Chemie (free open access). Thanks for great collaboration on this work with Xinjian-ch and Christian Heinis. EPFL Chemistry onlinelibrary.wiley.com/doi/10.1002/an…

Cyclic Peptides for Drug Development (Christian Heinis and co-workers) EPFL Chemistry Alexander L. Nielsen Xinjian-ch #AngewandteReview #openaccess onlinelibrary.wiley.com/doi/10.1002/an…

Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets | Journal of the American Chemical Society #Lipinski #Ruleof5 #OrallyAvailable #Drugs #Protein #KRAS pubs.acs.org/doi/10.1021/ja…

Wow. Our review on #cyclicpeptides was the most read paper in Angewandte in October! It's great to see such interest in macrocycles :) Link to review (open access): onlinelibrary.wiley.com/doi/full/10.10…

Maturation of the [FeFe]-Hydrogenase: Direct Transfer of the (kappa3-cysteinate)FeII(CN)(CO)2 Complex B from HydG to HydE (Yvain Nicolet and co-workers) Institut de Biologie Structurale Juneina omeiri #AngewandteVIP #openaccess onlinelibrary.wiley.com/doi/10.1002/an…

Thanks CHIMIA for highlighting the work of Xingyu Liu 刘星宇 in collaboration with the Heinis group chimia.ch/chimia/article…

Darobactin Substrate Engineering and Computation Show Radical Stability Governs Ether versus C–C Bond Formation by Austin Woodard, Francesca Peccati, Claudio Navo, Gonzalo Jiménez-Osés, and Douglas Mitchell Chemistry at Illinois in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

The list of most-accessed papers in the past month includes contributions by MaulideGroup, @springgroupchem, ICIQ, @sumansar8, Xiaojia Zhao, Bristol Chemistry, Xinjian-ch What else? See the full list. ow.ly/kjUK50RFjeu

Thanks for the opportunity to present and collaborate at this event. I am truly grateful for the chance to exchange ideas and learn from such distinguished fellow researcher.

PANCS-Binders (phage-assisted noncontinuous selection of protein binders) screens multiple high-diversity protein libraries against a panel of dozens of targets for high-throughput binder discovery. nature.com/articles/s4159…