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NetID for scalable inference of lineage-specific gene regulatory networks from large scRNA-seq datasets now published. Amazing work by @KenWang89437252 from an internship (!) in my lab. genomebiology.biomedcentral.com/articles/10.11…

👀New on bioRxiv: Our high-throughput #SingleCellProteomics pipeline analyzing 1,536 single cells/experiment, identifying 3,000+ proteins/cell. Applied to tumor macrophages in a lung metastasis model, we found ~500 differentially expressed proteins. 🔗 biorxiv.org/content/10.110…

Human evolution Source: visualcapitalist #evolution #Human #Biology

We are happy to share our new paper. We identified il11 as a regenerative factor to stimulate heart regeneration. However, prolonged il11 treatment causes fibrosis due to persistent activation of the epicardium. nature.com/articles/s4146…

We are thrilled to share that our first paper from my new lab, Spateo (github.com/aristoteleo/sp…) for spatiotemporal modeling of molecular holograms, is now online in Cell: cell.com/cell/fulltext/…. Spateo is a comprehensive analytical framework for 3D whole-embryo spatiotemporal

I am pleased to present the latest work from our lab, a human heart-macrophage assembloid model powered by self-organization that incorporates autologous cardiac embryonic macrophages into human pluripotent stem cell-derived heart organoids: biorxiv.org/cgi/content/sh…

Hiring! I'm looking for a postdoc in machine learning of spatial single-cell data. Exciting project to develop methods for modelling cellular circuits in disease and regeneration of heart, liver and bone marrow using Xenium data from our lab. tinyurl.com/ymkvk7vn

NiCo is out! Our new algorithm for spatial transcriptome data analysis predicts the crosstalk of cell types co-localized in tissue niches and sheds light on the downstream effects of cell-cell interactions by inferring covarying gene programs. nature.com/articles/s4146…

Super excited to share that our manuscript is finally OUT @CellSystems!!🚨 Cold and hot fibrosis define clinically distinct cardiac pathologies. cell.com/cell-systems/f…🧵(1/)

Check out this nice "Tools of the Trade" piece in Nature Reviews Genetics by Ankit Agrawal on our NiCo algorithm for the analysis of single-cell spatial transcriptomics data from platforms like Xenium, MERSCOPE, seqFISH etc. Feel free to reach out for advice. nature.com/articles/s4157…

Research| Secco et al. present the CycleTrack genetic tracing method to visualise cardiomyocyte turnover in neonatal and adult mice, after myocardial infarction, and upon pro-regenerative stimulation. doi.org/10.1038/s44161… 👉rdcu.be/ecVZp Mauro Giacca

Perturb-FISH, a method that combines high-throughput imaging spatial transcriptomics with in situ guide RNA detection, allows for the analysis of molecular and functional states, with spatial resolution at the single-cell level Cell cell.com/cell/fulltext/…

Our paper plus the cover in Cell Systems on cardiac fibrosis. A novel insight on these pathologies with some therapeutic solutions.

Random question: In human brain, consciousness emerges from the neuron’s collective activity, despite no single neuron is conscious. Similarly, society comes from many individuals working together. Could collective consciousness also emerge at the societal level, as in the brain?

Extremely happy to share our study on the regulation of HSCs in the context of myocardial infarction! Driven by two amazing scientists in my lab - Jasmin and Maricarmen and co-led with the awesome cardiologist Timo! Huge thanks to all our collaborators 👏🏻👏🏻 MPI of Immunobiology & Epigenetics ETH Zurich

Developmental onset of planarian whole-body regeneration depends on axis reset: Current Biology cell.com/current-biolog…

NEW STUDY: Senolytic molecules that clear aged cells (like dasatinib + quercetin), slow age-related hearing loss in mice by protecting cochlear cells & reducing inflammation. You heard it here 🧵

Deep in the ocean… 📹AI