#TCR_Signal Diversification | Quantitative #Interactomics in Primary T cells unveils extent and dynamics | protein–protein network over 600s of stimulation | Bernard Malissen @univamu Nature Immunology buff.ly/2C0Rf1W | #2019_Oct_ReCap

Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two Distinct Types of ALS/FTD-Linked FUS Mutations dlvr.it/RMMRpD

The research published in Nature shows that the histone variant H2A.Z facilitates the licensing and activation of early DNA replication origins. go.nature.com/362tynm

What is a memory? An emerging view is that ensembles of engram cells explain how memories are formed and retrieved. In a new #SciMagReview, researchers discuss the evidence for engram cells as a substrate of memory, particularly in rodents. ($) fcld.ly/v3l4c6l

Human #B_Cell_Memory | An integrated multi-omic single cell atlas | Sean Bendall Stanford University bioRxiv buff.ly/2oheBNE | #2019_Oct_ReCap

#immune #SingleCell

#3d_genome #review

Omicron variants just came to WashU Virus Browser! go to virusgateway.wustl.edu -> Data Table -> Clade: GRA. Heads up: they have a lot of mutations! From now on we'll be updating the virusgateway in a more supervised manner. Expect more changes soon!!

WashU Virus Browser New Year Update! Omicron on the home page! Added ~100k new SARS-CoV-2 sequences to virusgateway.wustl.edu. Also, did you know that you can directly search for all sequences with a given mutation? Contributions: Daofeng Li Deepak Purushotham Jennifer Ann Karlow

Today, we’re unveiling new patented technology, codenamed Infinity, for a highly accurate and cost-effective long read workflow that will deliver contiguous data to address the final edge cases of the genome.

Happy to contribute to this wonderful and interesting work! Congratulations to Marco Orecchioni Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production science.org/doi/10.1126/sc…

the first batch of 2021 SARS-CoV-2 strains just came to virusgateway.wustl.edu!!

Thrilled to share with you our exciting new findings identifying a #lymphatic niche for intestinal stem cells, and exposing lymphatics as a central hub for niche factors that govern tissue regeneration. biorxiv.org/content/10.110… A thread 🧵 🤩

Enjoyed this history febs.onlinelibrary.wiley.com/doi/10.1111/fe… of cohesin by Julia Horsfield going back to Dale Dorsett studies from the 1990s on Cohesin in regulating long-range Enhancer-Promoter interactions of cut gene. Now I need to read: academic.oup.com/genetics/artic… academic.oup.com/genetics/artic…

New on virusgateway.wustl.edu: just imported UniProt SARS-CoV-2 annotation from UCSC UCSC Genome Browser. Huge shout-out to the UCSC team for compiling them!!

virusgateway.wustl.edu Feb update. Added about 50k SARS-CoV-2 sequences collected in early 2022 and late 2021. Also tried my best to cover all variants from all countries!

Excellent talk by Alice Lee. Her group develops scalable tools to identify de novo TE insertions in human genome sequencing data. Application to large dataset confirm germline TE insertion rate is ~1 in 20 human births. #dnasrc22 mobilednajournal.biomedcentral.com/articles/10.11…

Sashimi․py: a flexible toolkit for combinatorial analysis of genomic data: biorxiv.org/content/10.110…

The one and only @clementgoubert introduces GraffiTE, a versatile easy-to-use package to identify and analyze TE insertion polymorphisms using pan-genome graphs in any species. Very neat! #KSTE23

In the mouse, I believe the most NK cell-specific gene is Ly49h. I found its enhancer! Read about my discovery of MAP8 here: nature.com/articles/s4146… Many thanks to Ting Wang, Sytse Piersma , and Wayne Yokoyama for the tremendous support!